INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
/ metabolism
Arachidonate 12-Lipoxygenase
/ metabolism
Arachidonic Acid
/ metabolism
Arachidonic Acids
/ metabolism
Blood Platelets
Glucose
/ metabolism
Hydroxyeicosatetraenoic Acids
/ metabolism
Lactates
/ metabolism
Nucleic Acids
/ metabolism
Sulfhydryl Compounds
/ metabolism
eicosanoids
high-resolution mass spectrometry
liquid chromatography
pathogen reduction
platelet concentrates
platelets
trans-arachidonic acids
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
07 09 2022
07 09 2022
Historique:
received:
03
08
2022
revised:
01
09
2022
accepted:
05
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Pathogen inactivation techniques for blood products have been implemented to optimize clinically safe blood components supply. The INTERCEPT system uses amotosalen together with ultraviolet light wavelength A (UVA) irradiation. Irradiation-induced inactivation of nucleic acids may actually be accompanied by modifications of chemically reactive polyunsaturated fatty acids known to be important mediators of platelet functions. Thus, here, we investigated eicosanoids and the related fatty acids released upon treatment and during storage of platelet concentrates for 7 days, complemented by the analysis of functional and metabolic consequences of these treatments. Metabolic and functional issues like glucose consumption, lactate formation, platelet aggregation, and clot firmness hardly differed between the two treatment groups. In contrast to gamma irradiation, here, we demonstrated that INTERCEPT treatment immediately caused new formation of
Identifiants
pubmed: 36139096
pii: biom12091258
doi: 10.3390/biom12091258
pmc: PMC9496540
pii:
doi:
Substances chimiques
Arachidonic Acids
0
Hydroxyeicosatetraenoic Acids
0
Lactates
0
Nucleic Acids
0
Sulfhydryl Compounds
0
Arachidonic Acid
27YG812J1I
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
59985-28-3
Arachidonate 12-Lipoxygenase
EC 1.13.11.31
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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