Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1.
Blood Platelets
/ metabolism
Factor XIIIa
/ metabolism
Fibrin
/ metabolism
Hirudins
/ metabolism
P-Selectin
/ metabolism
Phosphatidylserines
/ metabolism
Platelet Activation
Platelet Aggregation
Platelet Glycoprotein GPIIb-IIIa Complex
/ metabolism
Platelet Membrane Glycoproteins
/ metabolism
Protein C
/ metabolism
Receptor, PAR-1
/ metabolism
Syk Kinase
/ metabolism
Thrombin
/ metabolism
activated protein C
coagulation
coagulation factor XIIIa
glycoprotein VI
platelet activation
protease-activated receptor 1
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Sep 2022
06 Sep 2022
Historique:
received:
12
08
2022
revised:
24
08
2022
accepted:
30
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Platelet and coagulation activation are highly reciprocal processes driven by multi-molecular interactions. Activated platelets secrete several coagulation factors and expose phosphatidylserine, which supports the activation of coagulation factor proteins. On the other hand, the coagulation cascade generates known ligands for platelet receptors, such as thrombin and fibrin. Coagulation factor (F)Xa, (F)XIIIa and activated protein C (APC) can also bind to platelets, but the functional consequences are unclear. Here, we investigated the effects of the activated (anti)coagulation factors on platelets, other than thrombin. Multicolor flow cytometry and aggregation experiments revealed that the 'supernatant of (hirudin-treated) coagulated plasma' (SCP) enhanced CRP-XL-induced platelet responses, i.e., integrin α
Identifiants
pubmed: 36142125
pii: ijms231810203
doi: 10.3390/ijms231810203
pmc: PMC9499330
pii:
doi:
Substances chimiques
Hirudins
0
P-Selectin
0
Phosphatidylserines
0
Platelet Glycoprotein GPIIb-IIIa Complex
0
Platelet Membrane Glycoproteins
0
Protein C
0
Receptor, PAR-1
0
Fibrin
9001-31-4
Factor XIIIa
EC 2.3.2.13
Syk Kinase
EC 2.7.10.2
Thrombin
EC 3.4.21.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Marie Curie
ID : 766118
Pays : United Kingdom
Organisme : Hartstichting
ID : 2020T020
Références
Physiol Rev. 2013 Jan;93(1):327-58
pubmed: 23303912
J Thromb Haemost. 2003 Dec;1(12):2653-62
pubmed: 14675102
J Thromb Haemost. 2012 Dec;10(12):2418-27
pubmed: 23020554
Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2127-2142
pubmed: 32698684
J Biol Chem. 2009 Dec 4;284(49):33750-62
pubmed: 19815551
Blood. 1994 Feb 15;83(4):1006-16
pubmed: 7906563
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Blood. 2015 Jul 30;126(5):683-91
pubmed: 25977585
N Engl J Med. 2017 Oct 5;377(14):1319-1330
pubmed: 28844192
Nat Commun. 2014 Jul 16;5:4257
pubmed: 25027852
Nature. 1998 Aug 13;394(6694):690-4
pubmed: 9716134
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):e97-e111
pubmed: 33267658
J Thromb Haemost. 2013 Jan;11(1):2-16
pubmed: 23106920
Lancet. 2018 Jun 9;391(10137):2325-2334
pubmed: 29900874
Circulation. 2021 Nov 9;144(19):e287-e305
pubmed: 34601955
Blood. 2015 Mar 19;125(12):1976-85
pubmed: 25587041
Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1602-7
pubmed: 19661487
Res Pract Thromb Haemost. 2018 May 20;2(3):450-460
pubmed: 30046749
J Am Coll Cardiol. 2013 Jul 23;62(4):286-90
pubmed: 23602776
Blood Rev. 2009 Jul;23(4):177-89
pubmed: 19450911
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):E1372-80
pubmed: 22106258
Thromb Haemost. 2022 May;122(5):726-738
pubmed: 34689320
Blood. 2003 Jul 15;102(2):449-61
pubmed: 12649139
Blood. 2014 Dec 18;124(26):3982-90
pubmed: 25331118
Int J Mol Sci. 2019 Jun 07;20(11):
pubmed: 31181592
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E982-E991
pubmed: 29343648
J Thromb Haemost. 2008 Jun;6(6):995-1002
pubmed: 18489431
Blood. 2011 Apr 7;117(14):3912-20
pubmed: 21252089
J Biol Chem. 2004 Oct 29;279(44):45470-6
pubmed: 15317813
Blood. 2015 Sep 24;126(13):1601-8
pubmed: 26282541
PLoS One. 2014 Jul 17;9(7):e101446
pubmed: 25032959
Blood Rev. 2021 Mar;46:100733
pubmed: 32682574
J Thromb Haemost. 2011 Apr;9(4):820-33
pubmed: 21320283
J Thromb Haemost. 2017 Mar;15(3):549-564
pubmed: 28058806
Platelets. 2021 Jan 2;32(1):59-73
pubmed: 33455536
Thromb Res. 2002 Feb 15;105(4):317-23
pubmed: 12031826
Sci Rep. 2017 Jan 05;7:40002
pubmed: 28054640
Circ Res. 2020 Feb 14;126(4):486-500
pubmed: 31859592
Res Pract Thromb Haemost. 2022 Apr 24;6(3):e12697
pubmed: 35494504
Ann N Y Acad Sci. 2001;936:291-311
pubmed: 11460485
Curr Biol. 2001 Nov 13;11(22):1799-804
pubmed: 11719224
Nat Commun. 2020 Jun 12;11(1):2992
pubmed: 32532974