Cytotoxic Assessment of 3,3-Dichloro-β-Lactams Prepared through Microwave-Assisted Benzylic C-H Activation from Benzyl-Tethered Trichloroacetamides Catalyzed by RuCl
3,3-dichloro-β-lactams
A431 cell line
C-H activation
cytotoxic activity
hemocompatibility
microwaves
ruthenium catalysts
squamous cell carcinoma
trichloroacetamides
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Sep 2022
14 Sep 2022
Historique:
received:
01
08
2022
revised:
02
09
2022
accepted:
06
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Natural and synthetic β-lactam derivatives constitute an interesting class of compounds due to their diverse biological activity. Mostly used as antibiotics, they were also found to have antitubercular, anticancer and antidiabetic activities, among others. In this investigation, six new 3,3-dichloro-β-lactams prepared in a previous work were evaluated for their hemolytic and cytotoxic properties. The results showed that the proposed compounds have non-hemolytic properties and exhibited an interesting cytotoxic activity toward squamous cell carcinoma (A431 cell line), which was highly dependent on the structure and concentration of these β-lactams. Among the molecules tested,
Identifiants
pubmed: 36144721
pii: molecules27185975
doi: 10.3390/molecules27185975
pmc: PMC9500805
pii:
doi:
Substances chimiques
Acetamides
0
Antineoplastic Agents
0
Antitubercular Agents
0
Chloroacetates
0
Hypoglycemic Agents
0
beta-Lactams
0
trichloroacetamide
I8BL3305RO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundació Bosch i Gimpera
ID : 310959 and 309959
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