Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
04 01 2023
04 01 2023
Historique:
received:
27
04
2022
revised:
26
08
2022
accepted:
05
10
2022
pubmed:
11
10
2022
medline:
6
1
2023
entrez:
10
10
2022
Statut:
ppublish
Résumé
Tumor-associated macrophages (TAM) play an important role in supporting tumor growth and suppressing antitumor immune responses, and TAM infiltration has been associated with poor patient prognosis in various cancers. TAMs can be classified as pro-inflammatory, M1-like, or anti-inflammatory, M2-like. While multiple factors within the tumor microenvironment affect the recruitment, polarization, and functions of TAMs, accumulating evidence suggests that Wnt signaling represents an important, targetable driver of an immunosuppressive, M2-like TAM phenotype. TAM production of Wnt ligands mediates TAM-tumor cross-talk to support cancer cell proliferation, invasion, and metastasis. Targeting TAM polarization and the protumorigenic functions of TAMs through inhibitors of Wnt signaling may prove a beneficial treatment strategy in cancers where macrophages are prevalent in the microenvironment.
Identifiants
pubmed: 36214645
pii: 711847
doi: 10.1158/0008-5472.CAN-22-1403
pmc: PMC9812914
mid: NIHMS1842995
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-11Subventions
Organisme : NCI NIH HHS
ID : K12 CA090625
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA240901
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122516
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA272875
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA244188
Pays : United States
Informations de copyright
©2022 American Association for Cancer Research.
Références
Nature. 2015 Jul 9;523(7559):231-5
pubmed: 25970248
J Cell Biol. 2003 Sep 1;162(5):899-908
pubmed: 12952940
Science. 2014 May 23;344(6186):921-5
pubmed: 24812208
J Immunol. 2010 Jan 15;184(2):702-12
pubmed: 20018620
Cells. 2019 Nov 03;8(11):
pubmed: 31684152
Front Immunol. 2019 Sep 26;10:2293
pubmed: 31616443
J Biol Chem. 2018 Dec 14;293(50):19290-19302
pubmed: 30333225
Mol Neurobiol. 2019 Feb;56(2):1517-1530
pubmed: 29948952
J Immunother Cancer. 2019 Jul 19;7(1):190
pubmed: 31324218
Oncotarget. 2017 May 2;8(18):30576-30586
pubmed: 28427165
Int J Mol Sci. 2016 Mar 01;17(3):320
pubmed: 26938527
Dev Biol. 2007 Jun 1;306(1):121-33
pubmed: 17433286
Cell Rep. 2021 May 4;35(5):109071
pubmed: 33951424
Oncotarget. 2016 Jun 28;7(26):40451-40460
pubmed: 27248173
Immunity. 2013 Apr 18;38(4):792-804
pubmed: 23601688
Int J Mol Sci. 2021 Jun 29;22(13):
pubmed: 34209703
Nat Rev Immunol. 2011 Oct 10;11(11):762-74
pubmed: 21984070
Nat Immunol. 2013 Oct;14(10):986-95
pubmed: 24048120
Mol Carcinog. 2021 Jan;60(1):25-37
pubmed: 33283877
Cell. 2010 Apr 2;141(1):39-51
pubmed: 20371344
J Biol Chem. 2004 Jun 4;279(23):24659-65
pubmed: 15067007
Immunology. 2018 Feb;153(2):203-213
pubmed: 28872671
Dev Biol. 1976 Feb;48(2):461-5
pubmed: 815114
Cells. 2021 Apr 20;10(4):
pubmed: 33924237
J Immunother Cancer. 2019 May 28;7(1):140
pubmed: 31138333
Development. 2008 Nov;135(22):3719-29
pubmed: 18927149
J Immunol. 2012 Jun 1;188(11):5448-58
pubmed: 22547701
Int J Biol Sci. 2014 May 01;10(5):520-9
pubmed: 24910531
Mol Med Rep. 2021 Aug;24(2):
pubmed: 34080032
J Immunol. 2015 May 15;194(10):4997-5006
pubmed: 25876763
Mol Med Rep. 2017 Sep;16(3):3641-3647
pubmed: 28714032
Oncol Lett. 2018 Jun;15(6):8973-8982
pubmed: 29805633
J Biol Chem. 2012 Apr 6;287(15):11629-41
pubmed: 22356914
Future Oncol. 2019 Jul;15(19):2303-2317
pubmed: 31237146
Nature. 2009 Oct 1;461(7264):614-20
pubmed: 19759537
Science. 2012 Apr 6;336(6077):86-90
pubmed: 22442384
J Immunother Cancer. 2021 Jan;9(1):
pubmed: 33504575
Cell Death Dis. 2018 Jul 18;9(8):793
pubmed: 30022048
Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4041-E4050
pubmed: 29632196
Immunity. 2003 Jul;19(1):71-82
pubmed: 12871640
Front Immunol. 2020 Feb 17;11:122
pubmed: 32132993
Cancer Res. 2010 Jul 15;70(14):5728-39
pubmed: 20570887
Nat Rev Immunol. 2008 Dec;8(12):958-69
pubmed: 19029990
Cell. 2005 Mar 25;120(6):857-71
pubmed: 15797385
Nature. 2000 Sep 28;407(6803):527-30
pubmed: 11029006
J Immunol. 1987 Dec 1;139(11):3703-9
pubmed: 2824612
Int Immunopharmacol. 2014 Nov;23(1):37-45
pubmed: 25130606
Nat Rev Clin Oncol. 2017 Dec;14(12):717-734
pubmed: 28741618
Cell Physiol Biochem. 2015;35(4):1289-302
pubmed: 25721714
Dev Biol. 2012 Sep 1;369(1):101-14
pubmed: 22771246
Front Oncol. 2020 Jan 24;9:1512
pubmed: 32039007
J Immunother Precis Oncol. 2021 May 14;4(2):105-114
pubmed: 35663534
Nat Rev Immunol. 2014 Jun;14(6):392-404
pubmed: 24854589
Growth Factors. 2013 Feb;31(1):1-31
pubmed: 23256519
Clin Cancer Res. 2019 May 15;25(10):3074-3083
pubmed: 30635339
Adv Radiat Oncol. 2018 Oct 23;3(4):520-526
pubmed: 30370351
Mol Immunol. 2022 Jun;146:1-8
pubmed: 35395473
Sci Signal. 2008 Sep 02;1(35):re9
pubmed: 18765832
Cold Spring Harb Perspect Biol. 2012 Oct 01;4(10):
pubmed: 22935904
Cell Stem Cell. 2009 Jun 5;4(6):535-47
pubmed: 19497282
Glia. 2011 Jan;59(1):119-31
pubmed: 20967887
J Leukoc Biol. 2013 Jun;93(6):875-81
pubmed: 23505314
Commun Biol. 2019 May 9;2:176
pubmed: 31098409
Cancer Manag Res. 2019 May 03;11:4041-4058
pubmed: 31118813
Oncotarget. 2013 Nov;4(11):2057-66
pubmed: 24185202
Eur Heart J. 2011 Nov;32(22):2841-50
pubmed: 21398644
Cell. 2002 Mar 22;108(6):837-47
pubmed: 11955436
Mol Ther. 2018 Nov 7;26(11):2567-2579
pubmed: 30274786
Cancer Cell. 2014 Nov 10;26(5):638-52
pubmed: 25446897
Sci Adv. 2020 Jun 05;6(23):eaaz6105
pubmed: 32548260
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5165-70
pubmed: 19289839
J Cell Biol. 2000 Apr 17;149(2):249-54
pubmed: 10769018
Nat Rev Mol Cell Biol. 2012 Dec;13(12):767-79
pubmed: 23151663
Cancer Treat Rev. 2018 Nov;70:178-189
pubmed: 30227299
PLoS Biol. 2006 Apr;4(4):e115
pubmed: 16602827
Front Aging Neurosci. 2020 May 14;12:110
pubmed: 32477095
Signal Transduct Target Ther. 2021 Feb 23;6(1):75
pubmed: 33619259
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Genes Cells. 2003 Jul;8(7):645-54
pubmed: 12839624
PLoS One. 2012;7(8):e42656
pubmed: 22880072
Nature. 2002 Aug 8;418(6898):636-41
pubmed: 12167861
Am J Respir Cell Mol Biol. 2017 Feb;56(2):191-201
pubmed: 27668462
Genet Mol Res. 2016 Dec 02;15(4):
pubmed: 27966749
Cytokine. 2012 Oct;60(1):242-8
pubmed: 22763043
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12682-7
pubmed: 15314234
EMBO J. 2000 Apr 17;19(8):1839-50
pubmed: 10775268
J Exp Clin Cancer Res. 2021 Jan 6;40(1):13
pubmed: 33407720
J Hematol Oncol. 2019 Jul 12;12(1):76
pubmed: 31300030
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Immunity. 2019 Jul 16;51(1):27-41
pubmed: 31315034
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5454-9
pubmed: 16569699
Cell Commun Signal. 2020 Mar 30;18(1):51
pubmed: 32228612
Nat Cell Biol. 2011 Dec 18;14(2):186-91
pubmed: 22179044
Biomark Res. 2014 Jan 07;2(1):1
pubmed: 24398220
Blood. 2006 Aug 1;108(3):965-73
pubmed: 16601243
J Am Soc Nephrol. 2018 Jan;29(1):182-193
pubmed: 29021383
Acta Biochim Biophys Sin (Shanghai). 2011 Oct;43(10):745-56
pubmed: 21903638
Cancer Metastasis Rev. 2020 Sep;39(3):933-952
pubmed: 32435939
Cancers (Basel). 2021 Feb 20;13(4):
pubmed: 33672668
Immunity. 2018 Jan 16;48(1):147-160.e7
pubmed: 29343435
Cancer Res. 2019 Aug 15;79(16):4160-4172
pubmed: 31266773
Dev Biol. 2015 Feb 1;398(1):80-96
pubmed: 25482987
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16690-16701
pubmed: 32601235
FASEB J. 2010 Nov;24(11):4599-612
pubmed: 20667980
Genes Dev. 2010 Nov 15;24(22):2517-30
pubmed: 21078818
Blood. 2002 Jan 1;99(1):111-20
pubmed: 11756160