Sex dimorphism of weight and length at birth: evidence based on disorders of sex development.
Intrauterine
Turner syndrome
androgen
chromosome
congenital adrenal hyperplasia
Journal
Annals of human biology
ISSN: 1464-5033
Titre abrégé: Ann Hum Biol
Pays: England
ID NLM: 0404024
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
pubmed:
12
10
2022
medline:
3
3
2023
entrez:
11
10
2022
Statut:
ppublish
Résumé
Males have higher weight and length at birth than females. To verify the influence of the Y chromosome and the action of intrauterine androgens on weight and length at birth of children with Disorders of Sex Development (DSD). A cross-sectional and retrospective study. Patients with Turner syndrome (TS), complete (XX and XY), mixed (45,X/46,XY) and partial (XY) gonadal dysgenesis (GD), complete (CAIS) and partial (PAIS) androgen insensitivity syndromes and XX and XY congenital adrenal hyperplasia (CAH) were included. Weight and length at birth were evaluated. Weight and length at birth were lower in TS and mixed GD when compared to XY and XX DSD cases. In turn, patients with increased androgen action (117 cases) had higher weight and length at birth when compared to those with absent (108 cases) and decreased (68 cases) production/action. In birthweight, there was a negative influence of the 45,X/46,XY karyotype and a positive influence of increased androgen and gestational age. In birth length, there was a negative influence of the 45,X and 45,X/46,XY karyotypes and also a positive influence of increased androgen and gestational age. The sex dimorphism of weight and length at birth could possibly be influenced by intrauterine androgenic action.
Sections du résumé
BACKGROUND
UNASSIGNED
Males have higher weight and length at birth than females.
AIM
UNASSIGNED
To verify the influence of the Y chromosome and the action of intrauterine androgens on weight and length at birth of children with Disorders of Sex Development (DSD).
SUBJECTS AND METHODS
UNASSIGNED
A cross-sectional and retrospective study. Patients with Turner syndrome (TS), complete (XX and XY), mixed (45,X/46,XY) and partial (XY) gonadal dysgenesis (GD), complete (CAIS) and partial (PAIS) androgen insensitivity syndromes and XX and XY congenital adrenal hyperplasia (CAH) were included. Weight and length at birth were evaluated.
RESULTS
UNASSIGNED
Weight and length at birth were lower in TS and mixed GD when compared to XY and XX DSD cases. In turn, patients with increased androgen action (117 cases) had higher weight and length at birth when compared to those with absent (108 cases) and decreased (68 cases) production/action. In birthweight, there was a negative influence of the 45,X/46,XY karyotype and a positive influence of increased androgen and gestational age. In birth length, there was a negative influence of the 45,X and 45,X/46,XY karyotypes and also a positive influence of increased androgen and gestational age.
CONCLUSIONS
UNASSIGNED
The sex dimorphism of weight and length at birth could possibly be influenced by intrauterine androgenic action.
Identifiants
pubmed: 36218438
doi: 10.1080/03014460.2022.2134452
doi:
Substances chimiques
Androgens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM