Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 10 2022
12 10 2022
Historique:
received:
19
05
2022
accepted:
19
09
2022
entrez:
12
10
2022
pubmed:
13
10
2022
medline:
15
10
2022
Statut:
epublish
Résumé
Meiotic crossovers are limited in number and are prevented from occurring close to each other by crossover interference. In many species, crossover number is subject to sexual dimorphism, and a lower crossover number is associated with shorter chromosome axes lengths. How this patterning is imposed remains poorly understood. Here, we show that overexpression of the Arabidopsis pro-crossover protein HEI10 increases crossovers but maintains some interference and sexual dimorphism. Disrupting the synaptonemal complex by mutating ZYP1 also leads to an increase in crossovers but, in contrast, abolishes interference and disrupts the link between chromosome axis length and crossovers. Crucially, combining HEI10 overexpression and zyp1 mutation leads to a massive and unprecedented increase in crossovers. These observations support and can be predicted by, a recently proposed model in which HEI10 diffusion along the synaptonemal complex drives a coarsening process leading to well-spaced crossover-promoting foci, providing a mechanism for crossover patterning.
Identifiants
pubmed: 36224180
doi: 10.1038/s41467-022-33472-w
pii: 10.1038/s41467-022-33472-w
pmc: PMC9556546
doi:
Substances chimiques
Arabidopsis Proteins
0
Chromosomal Proteins, Non-Histone
0
HEI10 protein, Arabidopsis
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5999Informations de copyright
© 2022. The Author(s).
Références
Genetics. 2019 Mar;211(3):847-859
pubmed: 30670541
Nat Genet. 2014 Feb;46(2):194-9
pubmed: 24390283
Nat Commun. 2020 Feb 20;11(1):989
pubmed: 32080174
Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):
pubmed: 33723072
Genome Biol. 2019 Dec 16;20(1):277
pubmed: 31842948
Nat Commun. 2022 Jul 2;13(1):3828
pubmed: 35780220
PLoS Genet. 2014 Jan 30;10(1):e1004042
pubmed: 24497834
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4052-60
pubmed: 27354520
Bioinformatics. 2018 Mar 1;34(5):867-868
pubmed: 29096012
Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2117865119
pubmed: 35576467
Biol Reprod. 2022 Jul 25;107(1):275-288
pubmed: 35191959
Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):
pubmed: 33782125
J Cell Sci. 2021 May 15;134(10):
pubmed: 34037217
Curr Biol. 2013 Nov 4;23(21):2090-9
pubmed: 24206843
Nature. 2000 Dec 14;408(6814):796-815
pubmed: 11130711
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Cell. 2019 Apr 4;177(2):326-338.e16
pubmed: 30879787
Philos Trans R Soc Lond B Biol Sci. 2017 Dec 19;372(1736):
pubmed: 29109219
Genes Dev. 2017 Feb 1;31(3):306-317
pubmed: 28223312
Nature. 2022 Jun;606(7913):E1-E3
pubmed: 35676433
PLoS Genet. 2021 Mar 17;17(3):e1009205
pubmed: 33730019
Nat Commun. 2021 Aug 3;12(1):4674
pubmed: 34344879
Elife. 2015 Oct 09;4:e08287
pubmed: 26452093
PLoS Genet. 2012;8(7):e1002799
pubmed: 22844245
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16018-16027
pubmed: 31324745
Genetics. 2016 Jul;203(3):1091-103
pubmed: 27184389
Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12400-12409
pubmed: 31147459
Chromosoma. 2019 Sep;128(3):181-198
pubmed: 31236671
Nature. 2013 Oct 31;502(7473):703-6
pubmed: 24107990
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2437-2442
pubmed: 29463699
Bioinformatics. 2015 Jul 15;31(14):2382-3
pubmed: 25765347
PLoS Comput Biol. 2018 Jan 26;14(1):e1005944
pubmed: 29373581
PLoS Genet. 2007 Jun;3(6):e106
pubmed: 17604455
Methods Mol Biol. 2017;1471:305-323
pubmed: 28349405
Elife. 2019 May 20;8:
pubmed: 31107238
PLoS Genet. 2020 Jun 9;16(6):e1008849
pubmed: 32516352
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2431-2436
pubmed: 29183972
Trends Genet. 2003 Nov;19(11):623-8
pubmed: 14585614
Annu Rev Genet. 2019 Dec 3;53:19-44
pubmed: 31430178
G3 (Bethesda). 2015 Jan 13;5(3):385-98
pubmed: 25585881
Nucleic Acids Res. 2012 Jan;40(Database issue):D1202-10
pubmed: 22140109
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4713-8
pubmed: 25825745
Genomics Proteomics Bioinformatics. 2021 Mar 9;:
pubmed: 33711466
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):10007-12
pubmed: 24958856
PLoS Genet. 2019 Jun 20;15(6):e1008201
pubmed: 31220082
PLoS Genet. 2012 Jul;8(7):e1002809
pubmed: 22792078
Bioinformatics. 2015 Jun 15;31(12):2032-4
pubmed: 25697820
Semin Cell Dev Biol. 2016 Jun;54:135-48
pubmed: 26927691
Science. 2012 Jun 22;336(6088):1588-90
pubmed: 22723424
Cytogenet Genome Res. 2010 Jul;129(1-3):143-53
pubmed: 20628250