C3G down-regulation enhances pro-migratory and stemness properties of oval cells by promoting an epithelial-mesenchymal-like process.
C3G
epithelial mesenchymal transition
migration
oval cells
stemness
Journal
International journal of biological sciences
ISSN: 1449-2288
Titre abrégé: Int J Biol Sci
Pays: Australia
ID NLM: 101235568
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
03
2022
accepted:
11
08
2022
entrez:
20
10
2022
pubmed:
21
10
2022
medline:
22
10
2022
Statut:
epublish
Résumé
Previous data indicate that C3G (RapGEF1) main isoform is highly expressed in liver progenitor cells (or oval cells) compared to adult mature hepatocytes, suggesting it may play an important role in oval cell biology. Hence, we have explored C3G function in the regulation of oval cell properties by permanent gene silencing using shRNAs. We found that C3G knock-down enhanced migratory and invasive ability of oval cells by promoting a partial epithelial to mesenchymal transition (EMT). This is likely mediated by upregulation of mRNA expression of the EMT-inducing transcription factors,
Identifiants
pubmed: 36263169
doi: 10.7150/ijbs.73192
pii: ijbsv18p5873
pmc: PMC9576514
doi:
Substances chimiques
Transcription Factors
0
Transforming Growth Factor beta
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5873-5884Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
Références
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9912-7
pubmed: 16782807
Annu Rev Pathol. 2020 Jan 24;15:23-50
pubmed: 31399003
Cancers (Basel). 2020 Aug 14;12(8):
pubmed: 32823931
Cell Signal. 2010 Mar;22(3):533-42
pubmed: 19925863
Cell Signal. 2009 Jul;21(7):1229-35
pubmed: 19324082
Liver Res. 2017 Sep;1(2):81-87
pubmed: 29276644
Liver Int. 2017 Sep;37(9):1260-1271
pubmed: 28135758
Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2453-63
pubmed: 26001768
Cell Commun Signal. 2018 Dec 19;16(1):101
pubmed: 30567575
Hepatology. 2017 Oct;66(4):1183-1196
pubmed: 28407375
Biosci Rep. 2011 Aug;31(4):231-44
pubmed: 21366540
EMBO J. 2001 Jul 2;20(13):3333-41
pubmed: 11432821
Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G233-50
pubmed: 25477371
Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2629-39
pubmed: 26133694
Hepat Oncol. 2018 Apr 16;5(1):HEP05
pubmed: 30302196
Oncogene. 1998 Feb 5;16(5):613-24
pubmed: 9482107
Cell Death Dis. 2021 Apr 6;12(4):348
pubmed: 33824275
J Proteomics. 2015 Jul 1;125:104-11
pubmed: 25982384
PLoS One. 2013;8(1):e53108
pubmed: 23301029
J Cell Physiol. 2008 Jun;215(3):846-55
pubmed: 18286537
Am J Pathol. 2008 May;172(5):1238-47
pubmed: 18385520
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
Cell Death Differ. 2013 Aug;20(8):1116-23
pubmed: 23686136
Hepatology. 2012 Apr;55(4):1215-26
pubmed: 22095660
Hepatology. 2011 Mar;53(3):964-73
pubmed: 21319194
Hepatology. 2005 Apr;41(4):809-18
pubmed: 15793848
Mol Biol Cell. 2017 Apr 1;28(7):984-995
pubmed: 28148649
Oncotarget. 2016 Jul 19;7(29):45060-45078
pubmed: 27286263
Sci Rep. 2020 Nov 2;10(1):18838
pubmed: 33139841
Biochim Biophys Acta. 2011 Mar;1813(3):456-65
pubmed: 21223981
Stem Cells. 2019 Aug;37(8):1108-1118
pubmed: 31108004
Cell Tissue Res. 2012 Jan;347(1):245-56
pubmed: 22006249
Int J Mol Sci. 2021 Sep 16;22(18):
pubmed: 34576182
Oncogene. 2004 Jun 17;23(28):4885-93
pubmed: 15077165
Cell. 2016 Jun 30;166(1):21-45
pubmed: 27368099
Exp Cell Res. 2006 Apr 1;312(6):938-48
pubmed: 16443220
Stem Cell Rev Rep. 2021 Aug;17(4):1465-1477
pubmed: 33624208
J Biol Chem. 2015 Feb 13;290(7):4383-97
pubmed: 25548290
Biochem Biophys Res Commun. 2020 Feb 19;:
pubmed: 32087972