Chemical and Bioactivity Diversity of 2-(2-Phenylethyl)chromones in Agarwood: A Review.
2-(2-phenylethyl)chromones
agarwood
bioactivity
chemical
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
18
05
2022
accepted:
18
10
2022
pubmed:
21
10
2022
medline:
28
12
2022
entrez:
20
10
2022
Statut:
ppublish
Résumé
2-(2-Phenylethyl)chromone derivatives are regarded as key components in agarwood. An oxygen-containing heterocycle with a benzoannelated γ-pyrone moiety form the bioactive core of 2-(2-phenylethyl)chromones. With different substituents and positions, 2-(2-phenylethyl)chromone derivatives exhibit diverse biological properties, such as antioxidant, antimicrobial, neuroprotective, anti-inflammatory, and acetylcholinesterase inhibitory activities. In this review, we summarized the studies (from January 1976 to September 2021) on phytochemistry, bioactivity and quality control of 2-(2-phenylethyl)chromones. These studies aimed to clarify the chemical specificity, diversity and structure-activity relationship of 2-(2-phenylethyl)chromones. In addition, we assumed that diverse factors such as tree species, induction methods and formation time contribute to the chemical diversity of 2-(2-phenylethyl)chromones. Furthermore, this review contends that different types of 2-(2-phenylethyl)chromones should be utilized in the quality control methods of agarwood.
Identifiants
pubmed: 36266258
doi: 10.1002/cbdv.202200490
doi:
Substances chimiques
Chromones
0
2-(2-phenylethyl)chromone
61828-53-3
Acetylcholinesterase
EC 3.1.1.7
Flavonoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200490Subventions
Organisme : National Key Research and Development Project of China
ID : 2018YFC1706403
Organisme : Hainan Provincial Natural Science Foundation of China
ID : 2019RC340
Organisme : Key Research and Development Plan Projects of Hainan Province
ID : ZDYF2020163
Organisme : Key Research and Development Plan Projects of Hainan Province
ID : ZDYF2021SHFZ047
Organisme : CAMS Innovation Fund for Medical Sciences
ID : 2021-1-I2M-032
Informations de copyright
© 2022 Wiley-VHCA AG, Zurich, Switzerland.
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