Structural biology of DOCK-family guanine nucleotide exchange factors.


Journal

FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157

Informations de publication

Date de publication:
03 2023
Historique:
revised: 10 10 2022
received: 24 08 2022
accepted: 11 10 2022
medline: 29 3 2023
pubmed: 23 10 2022
entrez: 22 10 2022
Statut: ppublish

Résumé

DOCK proteins are a family of multi-domain guanine nucleotide exchange factors (GEFs) that activate the RHO GTPases CDC42 and RAC1, thereby regulating several RHO GTPase-dependent cellular processes. DOCK proteins are characterized by the catalytic DHR2 domain (DOCK

Identifiants

pubmed: 36271211
doi: 10.1002/1873-3468.14523
pmc: PMC10152721
doi:

Substances chimiques

Guanine Nucleotide Exchange Factors 0
cdc42 GTP-Binding Protein EC 3.6.5.2
rho GTP-Binding Proteins EC 3.6.5.2
Nucleotides 0
rac1 GTP-Binding Protein EC 3.6.5.2

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

794-810

Subventions

Organisme : Medical Research Council
ID : MC_UP_1201/6
Pays : United Kingdom
Organisme : CIHR
ID : PJT-153065
Pays : Canada
Organisme : Cancer Research UK
ID : C576/A14109
Pays : United Kingdom

Informations de copyright

© 2022 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

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Auteurs

Andreas Boland (A)

Department of Molecular and Cellular Biology, University of Geneva, Switzerland.

Jean-Francois Côté (JF)

Montreal Clinical Research Institute (IRCM), Canada.
Department of Medicine and Department of Biochemistry and Molecular Medicine, Université de Montréal, Canada.

David Barford (D)

MRC Laboratory of Molecular Biology, Cambridge, UK.

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Classifications MeSH