Structure-Activity Relationship Study of

Momordica / chemistry Adjuvants, Vaccine Saponins / chemistry Adjuvants, Immunologic / pharmacology Structure-Activity Relationship

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
10 11 2022
Historique:
pubmed: 2 11 2022
medline: 15 11 2022
entrez: 1 11 2022
Statut: ppublish

Résumé

VSA-2 is a recently developed semisynthetic saponin immunostimulant. It is prepared by incorporating a terminal-functionalized side chain to the branched trisaccharide domain at the C3 position of

Identifiants

DOI: 10.1021/acs.jmedchem.2c01087 PMID: 36318612 PMC: PMC10202417
pubmed: 36318612
doi: 10.1021/acs.jmedchem.2c01087
pmc: PMC10202417
mid: NIHMS1897359
doi:

Substances chimiques

Adjuvants, Vaccine 0
Saponins 0
Adjuvants, Immunologic 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

14589-14598

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI148711
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM120159
Pays : United States

Références

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Auteurs

Hyunjung Kim (H)

Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.

Di Bai (D)

Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.

Sadashib Ghosh (S)

Department of Neurosurgery, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.

Michael L Franks (ML)

Department of Neurosurgery, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.

Xifeng Wang (X)

Department of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.

Cheng Yan (C)

Department of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.

Zheng Liu (Z)

Department of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.

Ping Zhang (P)

Department of Pediatric Dentistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.

Suzanne M Michalek (SM)

Department of Microbiology, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.

Jianmei W Leavenworth (JW)

Department of Neurosurgery, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Department of Microbiology, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
The O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.

Pengfei Wang (P)

Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
The O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
ORCID: 0000-0002-0285-2069

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Cucurbitaceae › Momordica › Structure-Activity Relationship Study of
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Adjuvants pharmaceutiques › Adjuvants vaccinaux › Structure-Activity Relationship Study of
questionsmedicales.fr › Glucides › Hétérosides › Saponines › Structure-Activity Relationship Study of
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Adjuvants immunologiques › Structure-Activity Relationship Study of
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structure-Activity Relationship Study of