Combinatorial biosynthesis yields novel hybrid argimycin P alkaloids with diverse scaffolds in Streptomyces argillaceus.
Journal
Microbial biotechnology
ISSN: 1751-7915
Titre abrégé: Microb Biotechnol
Pays: United States
ID NLM: 101316335
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
06
10
2022
received:
23
06
2022
accepted:
19
10
2022
pubmed:
9
11
2022
medline:
15
12
2022
entrez:
8
11
2022
Statut:
ppublish
Résumé
Coelimycin P1 and argimycins P are two types of polyketide alkaloids produced by Streptomyces coelicolor and Streptomyces argillaceus, respectively. Their biosynthesis pathways share some early steps that render very similar aminated polyketide chains, diverging the pathways afterwards. By expressing the putative isomerase cpkE and/or the putative epoxidase/dehydrogenase cpkD from the coelimycin P1 gene cluster into S. argillaceus wild type and in argimycin mutant strains, five novel hybrid argimycins were generated. Chemical characterization of those compounds revealed that four of them show unprecedented scaffolds (quinolizidine and pyranopyridine) never found before in the argimycin family of compounds. One of these compounds (argimycin DM104) shows improved antibiotic activity. Noticeable, biosynthesis of these quinolizidine argimycins results from a hybrid pathway created by combining enzymes from two different pathways, which utilizes an aminated polyketide chain as precursor instead of lysine as it occurs for other quinolizidines.
Identifiants
pubmed: 36346129
doi: 10.1111/1751-7915.14167
pmc: PMC9733639
doi:
Substances chimiques
Plicamycin
NIJ123W41V
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2905-2916Subventions
Organisme : Gobierno del Principado de Asturias
ID : FC-15-GRUPIN14-014
Organisme : Secretaría de Estado de Investigación, Desarrollo e Innovación
ID : BIO2014-56752-R
Organisme : Secretaría de Estado de Investigación, Desarrollo e Innovación
ID : PIM2010EEI-00752
Informations de copyright
© 2022 The Authors. Microbial Biotechnology published by Applied Microbiology International and John Wiley & Sons Ltd.
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