A twist in Pitx2 regulation of gut looping.

Homeodomain Proteins / metabolism Gene Expression Regulation, Developmental Transcription Factors / metabolism Transforming Growth Factor beta / metabolism Signal Transduction Body Patterning / genetics

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
07 11 2022
Historique:
entrez: 8 11 2022
pubmed: 9 11 2022
medline: 11 11 2022
Statut: ppublish

Résumé

Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a "brake" to counteract BMP4 signaling on the right.

Identifiants

DOI: 10.1016/j.devcel.2022.10.006 PMID: 36347237
pubmed: 36347237
pii: S1534-5807(22)00758-4
doi: 10.1016/j.devcel.2022.10.006
pii:
doi:

Substances chimiques

Homeodomain Proteins 0
Transcription Factors 0
Transforming Growth Factor beta 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2445-2446

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Triveni Menon (T)

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Rebecca D Burdine (RD)

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: rburdine@princeton.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › A twist in Pitx2 regulation of gut looping.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › A twist in Pitx2 regulation of gut looping.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › A twist in Pitx2 regulation of gut looping.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › A twist in Pitx2 regulation of gut looping.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › A twist in Pitx2 regulation of gut looping.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Plan d'organisation du corps › A twist in Pitx2 regulation of gut looping.