Xenobiotic Receptors, a Journey of Rewards.

Receptors, Steroid / metabolism Xenobiotics Receptors, Cytoplasmic and Nuclear Gene Expression Regulation Carrier Proteins Reward

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
02 2023
Historique:
received: 30 01 2022
accepted: 20 10 2022
pmc-release: 01 02 2024
pubmed: 10 11 2022
medline: 31 1 2023
entrez: 9 11 2022
Statut: ppublish

Résumé

The xenobiotic nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were discovered or characterized in 1998. PXR and CAR have since been defined as master regulators of xenobiotic responses through their transcriptional regulation of drug-metabolizing enzymes and transporters. This article aims to provide an overview on the discovery of PXR and CAR as xenobiotic receptors.

Identifiants

DOI: 10.1124/dmd.122.000857 PMID: 36351836 PMC: PMC9900861
pubmed: 36351836
pii: dmd.122.000857
doi: 10.1124/dmd.122.000857
pmc: PMC9900861
doi:

Substances chimiques

Receptors, Steroid 0
Xenobiotics 0
Receptors, Cytoplasmic and Nuclear 0
Carrier Proteins 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

207-209

Informations de copyright

Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics.

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Auteurs

Wen Xie (W)

Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy and Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania wex6@pitt.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Xenobiotic Receptors, a Journey of Rewards.
questionsmedicales.fr › Préparations pharmaceutiques › Xénobiotique › Xenobiotic Receptors, a Journey of Rewards.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Xenobiotic Receptors, a Journey of Rewards.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Xenobiotic Receptors, a Journey of Rewards.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Xenobiotic Receptors, a Journey of Rewards.
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Renforcement (psychologie) › Récompense › Xenobiotic Receptors, a Journey of Rewards.