Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids.
allosteric modulation
cholesterol
muscarinic receptors
neuroactive steroids
neurosteroids
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Oct 2022
28 Oct 2022
Historique:
received:
19
09
2022
revised:
21
10
2022
accepted:
24
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones are molecules of steroid origin that, besides having well-known genomic effects, also modulate membrane proteins including muscarinic acetylcholine receptors. Here, we review current knowledge on the allosteric modulation of muscarinic receptors by these steroids. We give a perspective on the research on the non-genomic effects of steroidal compounds on muscarinic receptors and drug development, with an aim to ultimately exploit such knowledge.
Identifiants
pubmed: 36361865
pii: ijms232113075
doi: 10.3390/ijms232113075
pmc: PMC9656441
pii:
doi:
Substances chimiques
Neurosteroids
0
Hormones
0
Receptors, Muscarinic
0
Steroids
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union
ID : European Union - Next Generation EU, Programme EXCELES, ID Project No. LX22NPO5104
Organisme : Czech Academy of Sciences
ID : RVO:61388963
Organisme : Czech Academy of Sciences
ID : RVO:67985823
Références
Hum Reprod. 2000 Jun;15 Suppl 1:1-13
pubmed: 10928415
Front Neurosci. 2020 Jul 29;14:796
pubmed: 32848567
Front Cell Neurosci. 2016 Apr 22;10:101
pubmed: 27147973
J Neurosci. 2009 Nov 11;29(45):14271-86
pubmed: 19906975
J Steroid Biochem. 1988 Jan;29(1):111-8
pubmed: 3347044
Front Neurosci. 2015 Feb 20;9:37
pubmed: 25750611
Curr Neuropharmacol. 2007 Sep;5(3):157-67
pubmed: 19305798
Anesth Analg. 2003 Aug;97(2):449-455
pubmed: 12873933
Chem Phys Lipids. 2016 Sep;199:61-73
pubmed: 27108066
Biochem Biophys Res Commun. 2011 Jan 7;404(1):569-73
pubmed: 21146498
Naunyn Schmiedebergs Arch Pharmacol. 1985 Apr;329(2):176-81
pubmed: 4010794
Prog Neurobiol. 2009 Oct;89(2):134-52
pubmed: 19595736
Steroids. 2018 May;133:2-7
pubmed: 29155216
J Pharmacol Exp Ther. 1995 Jul;274(1):378-84
pubmed: 7616422
Trends Neurosci. 1999 Sep;22(9):410-6
pubmed: 10441302
Br J Pharmacol. 2006 Jul;148(5):565-78
pubmed: 16751797
Pharmacol Res. 2021 Jul;169:105641
pubmed: 33951507
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5554-8
pubmed: 6946492
Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):366-76
pubmed: 14564448
Naunyn Schmiedebergs Arch Pharmacol. 2005 Mar;371(3):221-8
pubmed: 15900516
Neuroendocrinology. 2012;96(2):162-71
pubmed: 22687885
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10978-83
pubmed: 18678919
Front Endocrinol (Lausanne). 2019 Apr 09;10:169
pubmed: 31024441
Steroids. 2016 Jun;110:77-87
pubmed: 27091763
Neurosci Biobehav Rev. 2010 Nov;35(2):303-14
pubmed: 20227436
Endocrinology. 1998 Dec;139(12):4991-7
pubmed: 9832438
J Steroid Biochem Mol Biol. 1990 Nov 20;37(3):395-403
pubmed: 2257243
Neuroendocrinology. 1981 May;32(5):295-302
pubmed: 7242856
Mol Pharmacol. 1998 Jun;53(6):1120-30
pubmed: 9614217
Front Aging Neurosci. 2019 Mar 01;11:43
pubmed: 30881301
Malays J Med Sci. 2018 Jul;25(4):31-41
pubmed: 30914845
Mol Pharmacol. 1994 May;45(5):983-90
pubmed: 8190113
Eur J Pharmacol. 1996 Jun 3;305(1-3):201-5
pubmed: 8813554
Nat Rev Mol Cell Biol. 2003 Jan;4(1):46-56
pubmed: 12511868
Front Pharmacol. 2018 Oct 02;9:1127
pubmed: 30333753
Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15950-5
pubmed: 19717450
Pharmacology. 1987;34(5):250-8
pubmed: 3615568
Nature. 2013 Dec 5;504(7478):101-6
pubmed: 24256733
Horm Behav. 2015 Aug;74:125-38
pubmed: 26122294
Neurochem Res. 2015 Oct;40(10):2068-77
pubmed: 24821386
Science. 1987 Jul 31;237(4814):527-32
pubmed: 3037705
J Mol Cell Cardiol. 1995 Sep;27(9):1831-9
pubmed: 8523444
Trends Pharmacol Sci. 2016 Jul;37(7):543-561
pubmed: 27156439
Front Endocrinol (Lausanne). 2011 Oct 11;2:50
pubmed: 22649375
Mini Rev Med Chem. 2005 Jun;5(6):523-43
pubmed: 15974931
Mol Pharmacol. 2001 Oct;60(4):761-7
pubmed: 11562438
Neuropharmacology. 2021 Nov 1;199:108798
pubmed: 34555368
Cell Commun Signal. 2020 Sep 9;18(1):146
pubmed: 32907599
Mol Pharmacol. 1983 May;23(3):551-7
pubmed: 6865905
Life Sci. 1988;42(23):2307-14
pubmed: 2836682
Wiley Interdiscip Rev Syst Biol Med. 2020 Jul;12(4):e1481
pubmed: 32032482
Horm Res. 1992;37 Suppl 3:1-10
pubmed: 1330863
Front Cell Neurosci. 2013 Jul 31;7:115
pubmed: 23914154
Curr Opin Struct Biol. 2020 Jun;62:14-21
pubmed: 31785465
Diabetes Obes Metab. 2007 Nov;9 Suppl 2:158-69
pubmed: 17919190
Pharmaceuticals (Basel). 2010 Aug 30;3(9):2838-2860
pubmed: 27713379
Structure. 2008 Jun;16(6):897-905
pubmed: 18547522
Biochim Biophys Acta. 2009 Feb;1788(2):295-302
pubmed: 19111523
Trends Biochem Sci. 2002 Dec;27(12):596-9
pubmed: 12468222
Biochem Pharmacol. 2021 Oct;192:114699
pubmed: 34324870
Cell Signal. 2009 Oct;21(10):1532-9
pubmed: 19520158
Brain Res. 1998 Jun 8;795(1-2):179-90
pubmed: 9622623
Dialogues Clin Neurosci. 2002 Jun;4(2):123-37
pubmed: 22033695
PLoS Comput Biol. 2007 Feb 23;3(2):e34
pubmed: 17319738
Prog Brain Res. 2010;186:113-37
pubmed: 21094889
Mol Pharmacol. 2000 Jul;58(1):194-207
pubmed: 10860942
Front Neurol. 2017 Aug 28;8:442
pubmed: 28894435
J Pharmacol Exp Ther. 2008 Dec;327(3):941-53
pubmed: 18772318
Mol Pharmacol. 2002 Dec;62(6):1492-505
pubmed: 12435818
Int J Mol Sci. 2014 Sep 01;15(9):15412-25
pubmed: 25257522
Front Neuroendocrinol. 2009 Aug;30(3):259-301
pubmed: 19505496
Brain Res. 2000 Jan 3;852(1):173-9
pubmed: 10661509
J Neurosci. 2016 Nov 9;36(45):11449-11458
pubmed: 27911748
Horm Behav. 2018 Aug;104:100-110
pubmed: 29727606
Front Mol Neurosci. 2018 Oct 05;11:359
pubmed: 30344476
Physiol Res. 2019 Apr 30;68(2):179-207
pubmed: 31037947
Mol Pharmacol. 1995 Oct;48(4):696-702
pubmed: 7476896
J Steroid Biochem Mol Biol. 2019 Oct;193:105409
pubmed: 31201927
Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9
pubmed: 11413487
J Comput Chem. 2017 Jun 15;38(16):1479-1488
pubmed: 27761918
Can J Physiol Pharmacol. 1992 Jul;70(7):943-8
pubmed: 1451031
Br J Pharmacol. 1976 Nov;58(3):323-31
pubmed: 990587
Pharmacol Ther. 1993 Jun;58(3):319-79
pubmed: 7504306
Mol Pharmacol. 2004 Jan;65(1):257-66
pubmed: 14722259
Drug Metab Rev. 2006;38(1-2):89-116
pubmed: 16684650
Psychoneuroendocrinology. 1998 Nov;23(8):963-87
pubmed: 9924747
Biosci Rep. 2012 Oct;32(5):423-32
pubmed: 22582733
Nature. 2009 May 21;459(7245):356-63
pubmed: 19458711
Neuroscience. 2005;132(1):57-64
pubmed: 15780466
Subcell Biochem. 2010;51:509-49
pubmed: 20213557
Front Neuroendocrinol. 2019 Oct;55:100788
pubmed: 31513776
Ann Endocrinol (Paris). 2003 Apr;64(2):158-61
pubmed: 12773955
Cell Mol Neurobiol. 2019 May;39(4):523-537
pubmed: 30187261
CNS Neurosci Ther. 2012 May;18(5):369-79
pubmed: 22070219
Br J Pharmacol. 2020 May;177(9):2073-2089
pubmed: 31910288
Front Endocrinol (Lausanne). 2020 Jun 24;11:417
pubmed: 32670200
Biomolecules. 2020 Feb 18;10(2):
pubmed: 32085536
J Psychiatr Res. 2001 May-Jun;35(3):127-45
pubmed: 11461709
Nat Rev Drug Discov. 2017 Dec;16(12):829-842
pubmed: 29075003
Neuroendocrinology. 2017;105(1):1-16
pubmed: 27894107
Biochem Biophys Res Commun. 1984 May 31;121(1):340-5
pubmed: 6732812
Neurosci Lett. 2021 Apr 17;750:135771
pubmed: 33636284
Mol Pharmacol. 2005 Sep;68(3):769-78
pubmed: 15937215
Handb Exp Pharmacol. 2012;(208):3-28
pubmed: 22222692
J Pharmacol Exp Ther. 2005 Oct;315(1):313-9
pubmed: 16002459
Neuroendocrinology. 1988 Apr;47(4):294-302
pubmed: 3374756
Eur J Pharmacol. 2009 Mar 15;606(1-3):50-60
pubmed: 19374848
Front Physiol. 2013 Feb 28;4:31
pubmed: 23450735
Int J Mol Sci. 2021 Feb 16;22(4):
pubmed: 33669406
Front Neuroendocrinol. 2019 Oct;55:100795
pubmed: 31562849
Respir Res. 2006 May 09;7:73
pubmed: 16684353
Biochem Biophys Res Commun. 1998 Mar 6;244(1):156-60
pubmed: 9514902
Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:31-50
pubmed: 31506010
Int Rev Neurobiol. 2015;123:27-85
pubmed: 26422982
Neuropharmacology. 2018 May 1;133:129-144
pubmed: 29407765
Nat Chem Biol. 2008 Jan;4(1):42-50
pubmed: 18059262
Neurochem Int. 2008 Mar-Apr;52(4-5):541-53
pubmed: 17624627