Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase.

Acetylcholinesterase / metabolism Molecular Docking Simulation Cholinesterase Inhibitors / chemistry Thiadiazoles / pharmacology Molecular Structure Structure-Activity Relationship Indoles / pharmacology
AchE and BuChE inhibitors SAR indole molecular docking thiadiazole analogs

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
29 Oct 2022
Historique:
received: 21 09 2022
revised: 14 10 2022
accepted: 25 10 2022
entrez: 11 11 2022
pubmed: 12 11 2022
medline: 15 11 2022
Statut: epublish

Résumé

The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (

Identifiants

DOI: 10.3390/molecules27217368 PMID: 36364195 PMC: PMC9657098
pubmed: 36364195
pii: molecules27217368
doi: 10.3390/molecules27217368
pmc: PMC9657098
pii:
doi:

Substances chimiques

Acetylcholinesterase EC 3.1.1.7
Cholinesterase Inhibitors 0
Thiadiazoles 0
Indoles 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : King Khalid University
ID : GRP/242/43
Organisme : Umm al-Qura University
ID : 22UQU4320141DSR77

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Auteurs

Shoaib Khan (S)

Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.
ORCID: 0000-0001-5404-0954

Shahid Iqbal (S)

Department of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST), H-12, Islamabad 46000, Pakistan.
ORCID: 0000-0002-4607-6217

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrah-Man Bin Faisal University, Dammam 34212, Saudi Arabia.

Fazal Rahim (F)

Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.

Mazloom Shah (M)

Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22500, Pakistan.

Hayat Ullah (H)

Department of Chemistry, University of Okara, Okara 56300, Pakistan.

Ali Bahadur (A)

Department of Chemistry, College of Science and Technology, Wenzhou-Kean University, Wenzhou 325060, China.
ORCID: 0000-0002-5329-6277

Hamad Alrbyawi (H)

Pharmaceutics and Pharmaceutical Technology Department, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia.
ORCID: 0000-0003-0820-3884

Ayed A Dera (AA)

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61413, Saudi Arabia.
ORCID: 0000-0002-6248-8983

Mohammed Issa Alahmdi (MI)

Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.

Rami Adel Pashameah (RA)

Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah 24230, Saudi Arabia.

Eman Alzahrani (E)

Department of Chemistry, College of Science, Taif University, Taif 21944, Saudi Arabia.

Abd-ElAziem Farouk (AE)

Department of Biotechnology, College of Science, Taif University, Taif 21944, Saudi Arabia.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Synthesis, In Vitro Biological Evaluation and...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis, In Vitro Biological Evaluation and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Synthesis, In Vitro Biological Evaluation and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › Thiadiazoles › Synthesis, In Vitro Biological Evaluation and...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis, In Vitro Biological Evaluation and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis, In Vitro Biological Evaluation and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Synthesis, In Vitro Biological Evaluation and...