Topography-mediated immunomodulation in osseointegration; Ally or Enemy.
BMP-2
Immunoengineering
Implant surface topography
Macrophage
Nano
Oncostatin M
Roughness
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
15
08
2022
revised:
02
11
2022
accepted:
04
11
2022
pubmed:
22
11
2022
medline:
30
11
2022
entrez:
21
11
2022
Statut:
ppublish
Résumé
Osteoimmunology is at full display during endosseous implant osseointegration. Bone formation, maintenance and resorption at the implant surface is a result of bidirectional and dynamic reciprocal communication between the bone and immune cells that extends beyond the well-defined osteoblast-osteoclast signaling. Implant surface topography informs adherent progenitor and immune cell function and their cross-talk to modulate the process of bone accrual. Integrating titanium surface engineering with the principles of immunology is utilized to harness the power of immune system to improve osseointegration in healthy and diseased microenvironments. This review summarizes current information regarding immune cell-titanium implant surface interactions and places these events in the context of surface-mediated immunomodulation and bone regeneration. A mechanistic approach is directed in demonstrating the central role of osteoimmunology in the process of osseointegration and exploring how regulation of immune cell function at the implant-bone interface may be used in future control of clinical therapies. The process of peri-implant bone loss is also informed by immunomodulation at the implant surface. How surface topography is exploited to prevent osteoclastogenesis is considered herein with respect to peri-implant inflammation, osteoclastic precursor-surface interactions, and the upstream/downstream effects of surface topography on immune and progenitor cell function.
Identifiants
pubmed: 36410109
pii: S0142-9612(22)00543-9
doi: 10.1016/j.biomaterials.2022.121903
pmc: PMC10148651
mid: NIHMS1891035
pii:
doi:
Substances chimiques
Titanium
D1JT611TNE
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
121903Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE027404
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE030495
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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