Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle.


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
07 12 2022
Historique:
pubmed: 29 11 2022
medline: 15 12 2022
entrez: 28 11 2022
Statut: ppublish

Résumé

Molecular machines, such as ATPases or motor proteins, couple the catalysis of a chemical reaction, most commonly hydrolysis of nucleotide triphosphates, to their conformational change. In essence, they continuously convert a chemical fuel to drive their motion. An outstanding goal of nanotechnology remains to synthesize a nanomachine with similar functions, precision, and speed. The field of DNA nanotechnology has given rise to the engineering precision required for such a device. Simultaneously, the field of systems chemistry developed fast chemical reaction cycles that convert fuel to change the function of molecules. In this work, we thus combined a chemical reaction cycle with the precision of DNA nanotechnology to yield kinetic control over the conformational state of a DNA hairpin. Future work on such systems will result in out-of-equilibrium DNA nanodevices with precise functions.

Identifiants

pubmed: 36442850
doi: 10.1021/jacs.2c08463
pmc: PMC9732876
doi:

Substances chimiques

DNA 9007-49-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

21939-21947

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Auteurs

Michele Stasi (M)

School of Natural Sciences, Department of Chemistry, Technical University of Munich, Garching85748, Germany.

Alba Monferrer (A)

School of Natural Sciences, Department of Physics, Technical University of Munich, Am Coulombwall 4, Garching85748, Germany.
Munich Institute of Biomedical Engineering, Technical University of Munich, Boltzmannstraße 11, Garching85748, Germany.

Leon Babl (L)

Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried82152,Germany.

Sreekar Wunnava (S)

Center for NanoScience (CeNS) and Systems Biophysics, Ludwig-Maximilian University Munich, Munich80799, Germany.

Christina Felicitas Dirscherl (CF)

Center for NanoScience (CeNS) and Systems Biophysics, Ludwig-Maximilian University Munich, Munich80799, Germany.

Dieter Braun (D)

Center for NanoScience (CeNS) and Systems Biophysics, Ludwig-Maximilian University Munich, Munich80799, Germany.

Petra Schwille (P)

Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried82152,Germany.

Hendrik Dietz (H)

School of Natural Sciences, Department of Physics, Technical University of Munich, Am Coulombwall 4, Garching85748, Germany.
Munich Institute of Biomedical Engineering, Technical University of Munich, Boltzmannstraße 11, Garching85748, Germany.

Job Boekhoven (J)

School of Natural Sciences, Department of Chemistry, Technical University of Munich, Garching85748, Germany.

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Classifications MeSH