On-DNA Alkyne Iodination and Acetylenic Coupling as a Useful Tool for DEL Synthesis.
Journal
Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319
Informations de publication
Date de publication:
21 12 2022
21 12 2022
Historique:
pubmed:
1
12
2022
medline:
23
12
2022
entrez:
30
11
2022
Statut:
ppublish
Résumé
1-Iodoalkynes and 1,3-diynes are versatile chemical intermediates and pharmaceutically valuable ingredients. In this study, copper mediated on-DNA alkyne iodination and Cadiot-Chodkiewicz coupling are developed for the first time. This generates diverse, systematic, and unprecedented topographic structural features, which could be invaluable as molecular recognition agents for drug discovery in DEL screening.
Identifiants
pubmed: 36450158
doi: 10.1021/acs.bioconjchem.2c00471
doi:
Substances chimiques
Alkynes
0
Acetylene
OC7TV75O83
Diynes
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM