Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage.

DNA Damage

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
06 12 2022
Historique:
entrez: 8 12 2022
pubmed: 9 12 2022
medline: 15 12 2022
Statut: ppublish

Résumé

The rapid increase of dNTP pools in mammalian cells upon DNA damage has been previously documented. Alterations in protein modifications or interactions can rapidly modulate the activity and protein stability of mammalian RNR, and activation of PRPS1/2-dependent generation of PRPP enhances the production of the indispensable ribose sugar for nucleotide biosynthesis.

Identifiants

DOI: 10.1016/j.cmet.2022.11.006 PMID: 36476930
pubmed: 36476930
pii: S1550-4131(22)00497-1
doi: 10.1016/j.cmet.2022.11.006
pii:
doi:

Substances chimiques

triphosphoric acid NU43IAG5BC

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1897-1898

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Rui Liu (R)

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: liurui_scu@hotmail.com.

Qianming Chen (Q)

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: qmchen@scu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Deoxyribonucleoside triphosphate pools in...