Phosphoproteomic Analysis of Dopamine D2 Receptor Signaling Reveals Interplay of G Protein- and β-Arrestin-Mediated Effects.
G protein
GPCRs
biased signaling
dopamine D2 receptor
functional selectivity
phosphoproteomics
proteome analysis
quinpirole
sulpiride
β-arrestin
Journal
Journal of proteome research
ISSN: 1535-3907
Titre abrégé: J Proteome Res
Pays: United States
ID NLM: 101128775
Informations de publication
Date de publication:
06 01 2023
06 01 2023
Historique:
pubmed:
13
12
2022
medline:
10
1
2023
entrez:
12
12
2022
Statut:
ppublish
Résumé
Leveraging biased signaling of G protein-coupled receptors has been proposed as a promising strategy for the development of drugs with higher specificity. However, the consequences of selectively targeting G protein- or β-arrestin-mediated signaling on cellular functions are not comprehensively understood. In this study, we utilized phosphoproteomics to gain a systematic overview of signaling induced by the four biased and balanced dopamine D2 receptor (D
Identifiants
pubmed: 36508580
doi: 10.1021/acs.jproteome.2c00707
pmc: PMC9831068
doi:
Substances chimiques
beta-Arrestins
0
Quinpirole
20OP60125T
Sulpiride
7MNE9M8287
Ligands
0
GTP-Binding Proteins
EC 3.6.1.-
Receptors, Dopamine D2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
259-271Références
Int J Neuropsychopharmacol. 2012 Aug;15(7):965-79
pubmed: 21777508
Stroke. 2015 Sep;46(9):2637-46
pubmed: 26251254
Clin Psychopharmacol Neurosci. 2013 Dec;11(3):144-51
pubmed: 24465251
Science. 2018 Jun 22;360(6395):
pubmed: 29930108
Nat Rev Drug Discov. 2018 Apr;17(4):243-260
pubmed: 29302067
Mol Pharmacol. 2014 Jul;86(1):96-105
pubmed: 24755247
Nat Commun. 2016 Jul 11;7:12178
pubmed: 27397672
Nature. 1996 Nov 7;384(6604 Suppl):14-6
pubmed: 8895594
J Med Chem. 2017 Jun 8;60(11):4693-4713
pubmed: 28489379
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12046-12050
pubmed: 30404914
Nature. 2013 Feb 7;494(7435):90-4
pubmed: 23242137
Pharmacol Ther. 2015 Apr;148:114-31
pubmed: 25435019
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93
pubmed: 22025698
Curr Vasc Pharmacol. 2009 Jul;7(3):267-76
pubmed: 19601851
Sci Rep. 2019 Nov 29;9(1):17894
pubmed: 31784636
J Exp Neurosci. 2018 May 31;12:1179069518779829
pubmed: 29899667
Trends Pharmacol Sci. 2011 Mar;32(3):148-57
pubmed: 21232805
ACS Pharmacol Transl Sci. 2019 Feb 8;2(1):52-65
pubmed: 30775693
J Biol Chem. 2020 May 8;295(19):6518-6531
pubmed: 32241914
Pharmacogenomics J. 2005;5(5):298-304
pubmed: 16027736
Pharmacol Rev. 2011 Mar;63(1):182-217
pubmed: 21303898
Nucleic Acids Res. 2019 Jul 2;47(W1):W191-W198
pubmed: 31066453
Br J Pharmacol. 1997 Jun;121(4):731-6
pubmed: 9208141
Nat Rev Drug Discov. 2010 May;9(5):373-86
pubmed: 20431569
J Neurosci. 2006 Nov 22;26(47):12339-50
pubmed: 17122059
J Biol Chem. 2013 Apr 12;288(15):10640-51
pubmed: 23457334
Nat Rev Drug Discov. 2017 Jan;16(1):19-34
pubmed: 27910877
Trends Pharmacol Sci. 2007 Aug;28(8):416-22
pubmed: 17644195
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Neuron. 2009 Oct 15;64(1):110-22
pubmed: 19840553
Cell. 2005 Jul 29;122(2):261-73
pubmed: 16051150
Eur J Neurosci. 2014 Jul;40(2):2463-70
pubmed: 24754803
Mol Syst Biol. 2016 Dec 1;12(12):888
pubmed: 27909043
BMC Genomics. 2011 Jan 07;12:14
pubmed: 21214938
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
J Med Chem. 2017 Apr 13;60(7):2908-2929
pubmed: 28248104
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
PLoS One. 2014 Mar 11;9(3):e91151
pubmed: 24618531
J Med Chem. 2012 Aug 23;55(16):7141-53
pubmed: 22845053
Front Neuroanat. 2011 Sep 06;5:58
pubmed: 21922001
Int J Mol Sci. 2020 Aug 24;21(17):
pubmed: 32847148
F1000Res. 2016 Jul 15;5:1717
pubmed: 27830058
Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):5039-5048
pubmed: 32071217
Pharmacol Ther. 2006 Oct;112(1):1-11
pubmed: 16644018
Oncol Lett. 2017 Dec;14(6):8171-8177
pubmed: 29344260
Br J Pharmacol. 2005 May;145(1):34-42
pubmed: 15735658
Genetics. 2011 Jul;188(3):579-90
pubmed: 21515580
Biophys J. 2012 Dec 5;103(11):2389-98
pubmed: 23283238
Sci Rep. 2021 Feb 10;11(1):3501
pubmed: 33568753
Bioinformation. 2007 May 20;2(1):5-7
pubmed: 18084642
Mol Cell Proteomics. 2003 Feb;2(2):96-106
pubmed: 12644571
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13656-61
pubmed: 18768802
Psychopharmacology (Berl). 2016 May;233(9):1715-23
pubmed: 26391290
Front Pharmacol. 2015 Mar 31;6:66
pubmed: 25873898
Front Mol Neurosci. 2014 Mar 11;7:16
pubmed: 24653673
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5099-104
pubmed: 15044694
Neuron. 2016 Feb 3;89(3):550-65
pubmed: 26804993
J Immunol. 2006 Jan 15;176(2):848-56
pubmed: 16393968
Annu Rev Physiol. 2007;69:483-510
pubmed: 17305471
Biochem Biophys Res Commun. 2014 Aug 8;450(4):1383-9
pubmed: 25019983
Sci Rep. 2019 Nov 14;9(1):16861
pubmed: 31727925
Mol Cell Endocrinol. 2013 Aug 15;375(1-2):58-67
pubmed: 23701824
J Neurosci. 2003 Apr 1;23(7):2840-50
pubmed: 12684471