The transcription factor AtMYB12 is part of a feedback loop regulating cell division orientation in the root meristem vasculature.
Arabidopsis thaliana
EMS screen
cytokinin
root development
transcription factors
vascular development
Journal
Journal of experimental botany
ISSN: 1460-2431
Titre abrégé: J Exp Bot
Pays: England
ID NLM: 9882906
Informations de publication
Date de publication:
28 03 2023
28 03 2023
Historique:
received:
21
06
2022
accepted:
09
01
2023
medline:
30
3
2023
pubmed:
19
1
2023
entrez:
18
1
2023
Statut:
ppublish
Résumé
Transcriptional networks are crucial to integrate various internal and external signals into optimal responses during plant growth and development. In Arabidopsis thaliana, primary root vasculature patterning and proliferation are controlled by a network centred around the basic Helix-Loop-Helix transcription factor complex, formed by TARGET OF MONOPTEROS 5 (TMO5) and LONESOME HIGHWAY (LHW), which control cell proliferation and division orientation by modulating the cytokinin response and other downstream factors. Despite recent progress, many aspects of the TMO5/LHW pathway are not fully understood. In particular, the upstream regulators of TMO5/LHW activity remain unknown. Here, using a forward genetics approach to identify new factors of the TMO5/LHW pathway, we discovered a novel function of the MYB-type transcription factor, MYB12. MYB12 physically interacts with TMO5 and dampens the TMO5/LHW-mediated induction of direct target gene expression, as well as the periclinal/radial cell divisions. The expression of MYB12 is activated by the cytokinin response, downstream of TMO5/LHW, resulting in a novel MYB12-mediated negative feedback loop that restricts TMO5/LHW activity, to ensure optimal cell proliferation rates during root vascular development.
Identifiants
pubmed: 36651677
pii: 6991119
doi: 10.1093/jxb/erad020
pmc: PMC7614412
mid: EMS173145
doi:
Substances chimiques
Arabidopsis Proteins
0
Transcription Factors
0
Trans-Activators
0
Cytokinins
0
LHW protein, Arabidopsis
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1940-1956Subventions
Organisme : European Research Council
ID : 682436
Pays : International
Organisme : European Research Council
ID : 714055
Pays : International
Organisme : European Research Council
ID : 949808
Pays : International
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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