Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure.
Autoimmunity
Chronic non-ischaemic heart failure
Heart failure
Pathophysiology
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
17
10
2022
received:
26
09
2022
accepted:
08
11
2022
medline:
30
3
2023
pubmed:
1
2
2023
entrez:
31
1
2023
Statut:
ppublish
Résumé
A causal link between non-ischaemic heart failure (HF) and humoral autoimmunity against G-protein-coupled receptors (GPCR) remains unclear except for Chagas' cardiomyopathy. Uncertainty arises from ambiguous reports on incidences of GPCR autoantibodies, spurious correlations of autoantibody levels with disease activity, and lack of standardization and validation of measuring procedures for putatively cardio-pathogenic GPCR autoantibodies. Here, we use validated and certified immune assays presenting native receptors as binding targets. We compared candidate GPCR autoantibody species between HF patients and healthy controls and tested associations of serum autoantibody levels with serological, haemodynamic, metabolic, and functional parameters in HF. Ninety-five non-ischaemic HF patients undergoing transcatheter endomyocardial biopsy and 60 healthy controls were included. GPCR autoantibodies were determined in serum by IgG binding to native receptors or a cyclic peptide (for β1AR autoantibodies). In patients, cardiac function, volumes, and myocardial structural properties were assessed by cardiac magnetic resonance imaging; right heart catheterization served for determination of cardiac haemodynamics; endomyocardial biopsies were used for histological assessment of cardiomyopathy and determination of cardiac mitochondrial oxidative function by high-resolution respirometry. Autoantibodies against β GPCR autoantibodies are markedly altered in HF. However, they are correlated poorly or even inversely to haemodynamic, metabolic, and functional markers of disease severity, myocardial histology, and myocardial mitochondrial efficiency. These observations do not hint towards a specific cardio-pathogenic role of GPCR autoantibodies and suggest that further investigations are required before specific therapies directed at GPCR autoantibodies can be clinically tested in non-ischaemic HF.
Identifiants
pubmed: 36717981
doi: 10.1002/ehf2.14293
pmc: PMC10053254
doi:
Substances chimiques
Autoantibodies
0
Angiotensin II
11128-99-7
Receptors, G-Protein-Coupled
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1258-1269Informations de copyright
© 2023 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
Références
Atheroscler Suppl. 2015 May;18:124-33
pubmed: 25936316
Eur J Heart Fail. 2019 May;21(5):553-576
pubmed: 30989768
J Card Fail. 1999 Sep;5(3):246-54
pubmed: 10496197
Methods Mol Biol. 2012;810:25-58
pubmed: 22057559
J Cardiovasc Magn Reson. 2017 Oct 9;19(1):75
pubmed: 28992817
J Clin Apher. 2005 Oct;20(3):137-42
pubmed: 15892087
J Am Coll Cardiol. 2017 Aug 8;70(6):807-808
pubmed: 28774387
Circ Res. 1989 Jan;64(1):97-103
pubmed: 2535798
Trends Pharmacol Sci. 2021 Mar;42(3):135-150
pubmed: 33358695
N Engl J Med. 2017 Apr 13;376(15):1407-1418
pubmed: 28402770
Int J Cardiol. 2016 Jan 1;202:728-30
pubmed: 26461921
J Cardiovasc Transl Res. 2021 Feb;14(1):75-87
pubmed: 32440911
Aging (Albany NY). 2020 Aug 28;12(16):16609-16620
pubmed: 32857064
J Am Soc Hypertens. 2009 Mar-Apr;3(2):133-40
pubmed: 20409953
Pharmacol Res. 2017 Nov;125(Pt A):39-47
pubmed: 28694144
J Allergy Clin Immunol. 1984 Nov;74(5):661-73
pubmed: 6209320
Methods Mol Biol. 2019;1955:247-261
pubmed: 30868533
Cardiovasc Res. 2013 Mar 1;97(3):472-80
pubmed: 23208588
Front Biosci (Landmark Ed). 2018 Jun 1;23(11):2065-2081
pubmed: 29772546
Nat Commun. 2018 Dec 6;9(1):5224
pubmed: 30523250
N Engl J Med. 2007 Mar 15;356(11):1140-51
pubmed: 17360992
Proc Assoc Am Physicians. 1999 May-Jun;111(3):241-8
pubmed: 10354364
Front Biosci (Landmark Ed). 2018 Jun 1;23(11):2146-2156
pubmed: 29772551
Diabetes Care. 2021 May;44(5):e82-e84
pubmed: 33972315
Pharmacol Res. 2017 Nov;125(Pt A):4-13
pubmed: 28527699
Circ Res. 2018 Feb 16;122(4):624-638
pubmed: 29449364
Int J Cardiol. 2016 Jul 1;214:83-5
pubmed: 27057984
Autoimmunity. 2000 Dec;32(4):271-80
pubmed: 11191286
Lupus. 2005;14(9):652-5
pubmed: 16218460
Clin Chem Lab Med. 2016 Apr;54(4):683-91
pubmed: 26408610
Am Heart J. 2006 Oct;152(4):697-704
pubmed: 16996841
Int J Cardiol. 2011 May 5;148(3):331-6
pubmed: 20053466
Europace. 2015 Feb;17(2):239-46
pubmed: 25238749
PLoS One. 2012;7(11):e48387
pubmed: 23155382
ESC Heart Fail. 2023 Apr;10(2):1258-1269
pubmed: 36717981
Sci Rep. 2016 Aug 31;6:32430
pubmed: 27577254
Front Biosci (Landmark Ed). 2018 Jun 1;23(11):2177-2194
pubmed: 29772554
PLoS One. 2018 Aug 20;13(8):e0201160
pubmed: 30125285
Circ Res. 2016 Jul 8;119(2):277-99
pubmed: 27390332
Eur J Heart Fail. 2013 Jul;15(7):724-9
pubmed: 23639780
Br J Pharmacol. 2012 Jun;166(3):847-57
pubmed: 22220626
J Mol Cell Cardiol. 2008 Feb;44(2):304-14
pubmed: 18155231
Circulation. 2007 Jul 24;116(4):399-410
pubmed: 17620508
Eur Heart J Cardiovasc Imaging. 2018 May 1;19(5):574-582
pubmed: 29136120
Int J Cardiol. 1996 May;54(2):127-35
pubmed: 8803676
Clin Immunol. 2016 Dec;173:64-75
pubmed: 27634429
Autoimmunity. 2008 Feb;41(1):35-45
pubmed: 18176863
Physiology (Bethesda). 2013 Jul;28(4):254-61
pubmed: 23817800
J Cardiovasc Transl Res. 2019 Apr;12(2):107-115
pubmed: 29589269
Biomed Biochim Acta. 1987;46(8-9):S634-9
pubmed: 2449194
Circ Heart Fail. 2020 Jan;13(1):e006155
pubmed: 31957469
ESC Heart Fail. 2020 Aug;7(4):1387-1399
pubmed: 32533765
Front Pediatr. 2022 Apr 28;10:881208
pubmed: 35573966
Eur J Heart Fail. 2012 Aug;14(8):887-94
pubmed: 22713286
Cardiology. 2015;131(3):149-50
pubmed: 25926265
Hypertension. 2015 Oct;66(4):830-5
pubmed: 26259590
ESC Heart Fail. 2020 Aug;7(4):1830-1841
pubmed: 32436653
Diabetes. 2018 Dec;67(12):2695-2702
pubmed: 30257974
J Vis Exp. 2013 Mar 08;(73):e4237
pubmed: 23524642
J Am Coll Cardiol. 2009 Sep 29;54(14):1309-16
pubmed: 19778674
Clin Drug Investig. 2020 May;40(5):433-447
pubmed: 32222912
Cardiovasc Res. 1976 Nov;10(6):613-22
pubmed: 825225
Mol Cell Endocrinol. 2013 Sep 25;378(1-2):59-69
pubmed: 22684034
Diabetologia. 2016 Aug;59(8):1778-90
pubmed: 27168137
Clin Pharmacol Ther. 2010 Apr;87(4):452-8
pubmed: 20054293
Clin Res Cardiol. 2007 Jul;96(7):469-80
pubmed: 17503113
ESC Heart Fail. 2020 Jun;7(3):844-855
pubmed: 32212256
Exp Mol Med. 2019 Feb 14;51(2):1-10
pubmed: 30765687
Heart Fail Rev. 2012 Jan;17(1):45-64
pubmed: 21165698
Front Biosci (Landmark Ed). 2019 Jan 1;24(1):48-95
pubmed: 30468647
Brain Behav Immun. 2016 Feb;52:32-39
pubmed: 26399744
Lancet Diabetes Endocrinol. 2014 Oct;2(10):843-51
pubmed: 24731668
Nat Rev Cardiol. 2021 Mar;18(3):169-193
pubmed: 33046850
Nature. 2019 Dec;576(7785):51-60
pubmed: 31802013
Exp Clin Endocrinol Diabetes. 2001;109 Suppl 2:S135-48
pubmed: 11460565
J Diabetes Res. 2016;2016:8917578
pubmed: 27652272
Eur J Clin Invest. 2010 Aug;40(8):685-91
pubmed: 20546018
Circulation. 1999 Feb 9;99(5):649-54
pubmed: 9950662