Late-onset sepsis in very preterm infants in Norway in 2009-2018: a population-based study.
Infant
Female
Infant, Newborn
Humans
Cohort Studies
Intensive Care Units, Neonatal
Infant, Premature, Diseases
/ epidemiology
Sepsis
/ epidemiology
Infant, Extremely Premature
Gestational Age
Bronchopulmonary Dysplasia
/ epidemiology
Retinopathy of Prematurity
/ epidemiology
Leukomalacia, Periventricular
/ epidemiology
Fetal Growth Retardation
Intensive Care Units, Neonatal
Microbiology
Neonatology
Sepsis
Journal
Archives of disease in childhood. Fetal and neonatal edition
ISSN: 1468-2052
Titre abrégé: Arch Dis Child Fetal Neonatal Ed
Pays: England
ID NLM: 9501297
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
05
10
2022
accepted:
13
01
2023
medline:
21
8
2023
pubmed:
3
2
2023
entrez:
2
2
2023
Statut:
ppublish
Résumé
To evaluate epidemiology and outcomes among very preterm infants (<32 weeks' gestation) with culture-positive and culture-negative late-onset sepsis (LOS). Cohort study using a nationwide, population-based registry. 21 neonatal units in Norway. All very preterm infants born 1 January 2009-31 December 2018 and admitted to a neonatal unit. Incidences, pathogen distribution, LOS-attributable mortality and associated morbidity at discharge. Among 5296 very preterm infants, we identified 582 culture-positive LOS episodes in 493 infants (incidence 9.3%) and 282 culture-negative LOS episodes in 282 infants (incidence 5.3%). Extremely preterm infants (<28 weeks' gestation) had highest incidences of culture-positive (21.6%) and culture-negative (11.1%) LOS. The major causative pathogens were coagulase-negative staphylococci (49%), LOS contributes to a significant burden of disease in very preterm infants and is associated with increased odds of severe BPD, cPVL and severe ROP.
Identifiants
pubmed: 36732047
pii: archdischild-2022-324977
doi: 10.1136/archdischild-2022-324977
pmc: PMC10447404
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
478-484Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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