Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase.
Journal
Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882
Informations de publication
Date de publication:
24 02 2023
24 02 2023
Historique:
pubmed:
11
2
2023
medline:
3
3
2023
entrez:
10
2
2023
Statut:
ppublish
Résumé
By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-terminal adenylation-thiolation didomain, which catalyzes the formation of naringenin chalcone, was found. Structural prediction and molecular docking analysis indicated that a C-terminal thioesterase domain was involved in the Claisen-type cyclization. An enzyme responsible for formation of (2
Identifiants
pubmed: 36762727
doi: 10.1021/acs.jnatprod.2c01027
pmc: PMC9972472
doi:
Substances chimiques
flavanone synthetase
EC 2.3.1.74
chalcone isomerase
EC 5.5.1.6
Flavonoids
0
Acyltransferases
EC 2.3.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
398-405Références
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