Animals Carboxylic Acids Heterocyclic Compounds Schistosoma mansoni Schistosomiasis / drug therapy
Schistosoma anthelminthics drug discovery ozonides pharmacokinetics schistosomiasis

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
10 03 2023
Historique:
pubmed: 17 2 2023
medline: 14 3 2023
entrez: 16 2 2023
Statut: ppublish

Résumé

Praziquantel, the only drug in clinical use for the treatment and control of schistosomiasis, is inactive against developing infections. Ozonides are synthetic peroxide derivatives inspired by the naturally occurring artemisinin and show particularly promising activity against juvenile schistosomes. We conducted an in-depth characterization of the

Identifiants

DOI: 10.1021/acsinfecdis.2c00581 PMID: 36794836
pubmed: 36794836
doi: 10.1021/acsinfecdis.2c00581
doi:

Substances chimiques

1,2,4-trioxane 0
Carboxylic Acids 0
Heterocyclic Compounds 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

643-652

Auteurs

Stefan Biendl (S)

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.
University of Basel, CH-4003 Basel, Switzerland.

Cécile Häberli (C)

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.
University of Basel, CH-4003 Basel, Switzerland.

Gong Chen (G)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Wen Wang (W)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Longjin Zhong (L)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Jessica Saunders (J)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Thao Pham (T)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Xiaofang Wang (X)

College of Pharmacy, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 986125, United States of America.

Jianbo Wu (J)

College of Pharmacy, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 986125, United States of America.

Susan A Charman (SA)

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
ORCID: 0000-0003-1753-8213

Jonathan L Vennerstrom (JL)

College of Pharmacy, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 986125, United States of America.
ORCID: 0000-0003-0075-2336

Jennifer Keiser (J)

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.
University of Basel, CH-4003 Basel, Switzerland.
ORCID: 0000-0003-0290-3521

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux ›
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques ›
questionsmedicales.fr › Composés hétérocycliques ›
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Trematoda › Schistosomatidae › Schistosoma › Schistosoma mansoni ›
questionsmedicales.fr › Infection › Maladies vectorielles › Schistosomiase ›