Synaptotagmin-7 facilitates acetylcholine release in splanchnic nerve-chromaffin cell synapses during nerve activity.

Acetylcholine / metabolism Synaptotagmins / metabolism Splanchnic Nerves / metabolism Chromaffin Cells / metabolism Adrenal Medulla / metabolism Synapses / physiology
Adrenal medulla Preganglionic synapses Synaptotagmin Synaptotagmin-7

Journal

Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130

Informations de publication

Date de publication:
13 03 2023
Historique:
received: 25 10 2021
revised: 23 01 2023
accepted: 11 02 2023
pmc-release: 13 03 2024
pubmed: 17 2 2023
medline: 3 3 2023
entrez: 16 2 2023
Statut: ppublish

Résumé

Disturbances that threaten homeostasis elicit activation of the sympathetic nervous system (SNS) and the adrenal medulla. The effectors discharge as a unit to drive global and immediate changes in whole-body physiology. Descending sympathetic information is conveyed to the adrenal medulla via preganglionic splanchnic fibers. These fibers pass into the gland and synapse onto chromaffin cells, which synthesize, store, and secrete catecholamines and vasoactive peptides. While the importance of the sympatho-adrenal branch of the autonomic nervous system has been appreciated for many decades, the mechanisms underlying transmission between presynaptic splanchnic neurons and postsynaptic chromaffin cells have remained obscure. In contrast to chromaffin cells, which have enjoyed sustained attention as a model system for exocytosis, even the Ca

Identifiants

DOI: 10.1016/j.neulet.2023.137129 PMID: 36796621 PMC: PMC10145958
pubmed: 36796621
pii: S0304-3940(23)00083-6
doi: 10.1016/j.neulet.2023.137129
pmc: PMC10145958
mid: NIHMS1894002
pii:
doi:

Substances chimiques

Acetylcholine N9YNS0M02X
Synaptotagmins 134193-27-4

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

137129

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS122534
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007767
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM140223
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

René N Caballero-Florán (RN)

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States.

Mounir Bendahmane (M)

Department of Neuroscience, University of Toledo, Toledo, OH 43614, United States.

Julie P Gupta (JP)

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States.

Xiaohuan Chen (X)

Department of Neuroscience, University of Toledo, Toledo, OH 43614, United States.

Xiaojun Wu (X)

Department of Neuroscience, University of Toledo, Toledo, OH 43614, United States.

Alina Morales (A)

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Neuroscience, University of Toledo, Toledo, OH 43614, United States.

Arun Anantharam (A)

Department of Neuroscience, University of Toledo, Toledo, OH 43614, United States. Electronic address: arun.anantharam@utoledo.edu.

Paul M Jenkins (PM)

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, United States. Electronic address: pjenkins@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › Synaptotagmin-7 facilitates acetylcholine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Synaptotagmines › Synaptotagmin-7 facilitates acetylcholine...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Voies nerveuses autonomes › Nerfs splanchniques › Synaptotagmin-7 facilitates acetylcholine...
questionsmedicales.fr › Cellules › Cellules chromaffines › Synaptotagmin-7 facilitates acetylcholine...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Glandes surrénales › Médulla surrénale › Synaptotagmin-7 facilitates acetylcholine...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Synaptotagmin-7 facilitates acetylcholine...