Investigations into Simplified Analogues of the Herbicidal Natural Product (+)-Cornexistin.
crop protection
herbicides
natural products
structure simplification
transketolase
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
11 Jul 2023
11 Jul 2023
Historique:
received:
19
01
2023
pmc-release:
11
07
2024
medline:
14
7
2023
pubmed:
23
2
2023
entrez:
22
2
2023
Statut:
ppublish
Résumé
We report the design, synthesis and biological evaluation of simplified analogues of the herbicidal natural product (+)-cornexistin. Guided by an X-Ray co-crystal structure of cornexistin bound to transketolase from Zea mays, we attempted to identify the key interactions that are necessary for cornexistin to maintain its herbicidal profile. This resulted in the preparation of three novel analogues investigating the importance of substituents that are located on the nine-membered ring of cornexistin. One analogue maintained a good level of biological activity and could provide researchers insights in how to further optimize the structure of cornexistin for commercialization in the future.
Identifiants
pubmed: 36807428
doi: 10.1002/chem.202300199
pmc: PMC7614749
mid: EMS174830
doi:
Substances chimiques
Herbicides
0
cornexistin
123068-35-9
Biological Products
0
Furans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300199Subventions
Organisme : Austrian Science Fund FWF
ID : P 31023
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 33894
Pays : Austria
Informations de copyright
© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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