R97 at "Handlebar" Binding Mode in Active Pocket Plays an Important Role in Fe(II)/α-Ketoglutaric Acid-Dependent Dioxygenase

L-pipecolic acid dioxygenase hydroxypipecolic acid site-directed saturation mutagenesis “handlebar” mode

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
15 Feb 2023
Historique:
received: 23 01 2023
revised: 11 02 2023
accepted: 13 02 2023
entrez: 25 2 2023
pubmed: 26 2 2023
medline: 3 3 2023
Statut: epublish

Résumé

Pipecolic acid (Pip) and its derivative hydroxypipecolic acids, such as (2S,3R)-3-hydroxypipecolic acid (

Identifiants

pubmed: 36838840
pii: molecules28041854
doi: 10.3390/molecules28041854
pmc: PMC9968057
pii:
doi:

Substances chimiques

Dioxygenases EC 1.13.11.-
3-hydroxypipecolic acid 0
Pipecolic Acids 0
Ketoglutaric Acids 0
Ferrous Compounds 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Key R&D Program of China
ID : 2021YFC2102000
Organisme : National Natural Science Foundation of China
ID : 22178147, 31872891
Organisme : Program of Introducing Talents of Discipline to Universities
ID : 111-2-06
Organisme : High-End Foreign Experts Recruitment Program
ID : G2021144005L

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Auteurs

Jiaojiao Guan (J)

Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.

Yilei Lu (Y)

Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.

Zixuan Dai (Z)

Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.

Songyin Zhao (S)

Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.

Yan Xu (Y)

Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Yao Nie (Y)

Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.
Suqian Industrial Technology Research Institute of Jiangnan University, Suqian 223814, China.

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Classifications MeSH