Multidrug-resistant Enterobacterales responsible for septicaemia in a neonatal intensive care unit in Morocco.
Infant, Newborn
Humans
Intensive Care Units, Neonatal
Klebsiella Infections
/ microbiology
Anti-Bacterial Agents
/ pharmacology
Multilocus Sequence Typing
Neonatal Sepsis
/ epidemiology
Morocco
/ epidemiology
beta-Lactamases
/ genetics
Klebsiella pneumoniae
/ genetics
Sepsis
/ drug therapy
Bacteremia
/ epidemiology
Carbapenemase-producing Enterobacterales
Extended-spectrum β-lactamases
Morocco
Neonatal intensive care unit
Outbreak
Sepsis
Journal
Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
16
01
2023
revised:
07
02
2023
accepted:
11
02
2023
medline:
20
6
2023
pubmed:
4
3
2023
entrez:
3
3
2023
Statut:
ppublish
Résumé
Neonatal sepsis caused by multidrug-resistant (MDR) bacteria has a high morbidity and mortality, especially in low- and middle-income countries. Here, the molecular mechanisms of multidrug resistance in bacteria responsible for neonatal sepsis were determined. From July to December 2019, documented bacteraemia from 524 neonates hospitalised in a neonatal intensive care unit in Morocco were collected. Whole-genome sequencing was used to characterise the resistome; multi-locus sequence typing was used to investigate phylogeny. Among the 199 cases of documented bacteraemia, 40 (20%) and 20 (10%) were caused by MDR Klebsiella pneumoniae and Enterobacter hormaechei, respectively. Of these, 23 (38.5%) were early neonatal infections (≤3 days of life). Twelve different sequence types (STs) were observed among K. pneumoniae isolates, the most prevalent being ST1805 (n = 10) and ST307 (n = 8). Twenty-one K. pneumoniae isolates (53%) possessed the bla Thirty percent of neonatal sepsis cases (23 early and 37 late) were caused by highly drug-resistant carbapenemase- and/or ESBL-producing Enterobacterales.
Identifiants
pubmed: 36868310
pii: S2213-7165(23)00029-2
doi: 10.1016/j.jgar.2023.02.011
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
208-217Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Competing interests None to declare.