Linoleic acid potentiates CD8
CD8 T cells
adoptive T cell therapy
linoleic acid
lipid metabolism
metabolic fitness
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
04 04 2023
04 04 2023
Historique:
received:
09
06
2022
revised:
19
12
2022
accepted:
15
02
2023
medline:
7
4
2023
pubmed:
11
3
2023
entrez:
10
3
2023
Statut:
ppublish
Résumé
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8
Identifiants
pubmed: 36898381
pii: S1550-4131(23)00049-9
doi: 10.1016/j.cmet.2023.02.013
pii:
doi:
Substances chimiques
Linoleic Acid
9KJL21T0QJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
633-650.e9Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests C.B.N.L., L.N., and T.M. reported a patent application related to this study. P.D.G. was a scientific consultant for Juno Therapeutics.