Analysis of human lung mast cells by single cell RNA sequencing.

carboxypeptidase A3 (CPA3) cathepsin G (CTSG) chymase (CMA1) heterogeniety lung mast cells (MC) single cell RNA sequencing

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 26 01 2023
accepted: 15 03 2023
medline: 18 4 2023
entrez: 17 4 2023
pubmed: 18 4 2023
Statut: epublish

Résumé

Mast cells are tissue-resident cells playing major roles in homeostasis and disease conditions. Lung mast cells are particularly important in airway inflammatory diseases such as asthma. Human mast cells are classically divided into the subsets MC

Identifiants

pubmed: 37063885
doi: 10.3389/fimmu.2023.1151754
pmc: PMC10100501
doi:

Substances chimiques

Chymases EC 3.4.21.39
Cathepsin G EC 3.4.21.20
Peptide Hydrolases EC 3.4.-
Tryptases EC 3.4.21.59

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1151754

Informations de copyright

Copyright © 2023 Rönnberg, Ravindran, Mazzurana, Gong, Säfholm, Lorent, Dethlefsen, Orre, Al-Ameri, Adner, Dahlén, Dahlin, Mjösberg and Nilsson.

Déclaration de conflit d'intérêts

S-ED reports personal fees from AstraZeneca, Cayman Chemicals, GSK, Novartis, Regeneron, Sanofi, and Teva, for consultancies outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Elin Rönnberg (E)

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.

Avinash Ravindran (A)

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Luca Mazzurana (L)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Yitao Gong (Y)

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.

Jesper Säfholm (J)

Unit for Experimental Asthma and Allergy Research Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Julie Lorent (J)

National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm University, Stockholm, Sweden.

Olga Dethlefsen (O)

National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm University, Stockholm, Sweden.

Ann-Charlotte Orre (AC)

Thoracic Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Mamdoh Al-Ameri (M)

Thoracic Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Mikael Adner (M)

Unit for Experimental Asthma and Allergy Research Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Sven-Erik Dahlén (SE)

Unit for Experimental Asthma and Allergy Research Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Joakim S Dahlin (JS)

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.

Jenny Mjösberg (J)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Gunnar Nilsson (G)

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

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Classifications MeSH