Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity.

DNA / chemistry Thymine / chemistry DNA Repair Endonucleases / metabolism

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
16 May 2023
Historique:
medline: 18 5 2023
pubmed: 2 5 2023
entrez: 2 5 2023
Statut: epublish

Résumé

Dimethyllumazine (DML)-thiazole orange (TO) conjugates were developed for fluorescence sensing of thymine glycol (Tg)-containing DNAs based on the selective recognition of the A nucleobase opposite the Tg residue. Additionally, this conjugate has demonstrated an inhibitory activity towards endonuclease III, a DNA repair enzyme, through its competitive binding to Tg-containing DNAs.

Identifiants

DOI: 10.1039/d3cc01501g PMID: 37128964
pubmed: 37128964
doi: 10.1039/d3cc01501g
doi:

Substances chimiques

thymine glycol 2943-56-8
DNA 9007-49-2
Thymine QR26YLT7LT
Endonucleases EC 3.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6088-6091

Auteurs

Yusuke Sato (Y)

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. yusuke.sato.a7@tohoku.ac.jp.
ORCID: 0000-0002-5824-1654

Yoshihide Takaku (Y)

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. yusuke.sato.a7@tohoku.ac.jp.

Toshiaki Nakano (T)

DNA damage chemistry research group, Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Kizugawa, 619-0215, Japan. akamatsu.ken@qst.go.jp.
ORCID: 0000-0002-5274-2909

Ken Akamatsu (K)

DNA damage chemistry research group, Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Kizugawa, 619-0215, Japan. akamatsu.ken@qst.go.jp.

Dai Inamura (D)

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. yusuke.sato.a7@tohoku.ac.jp.

Seiichi Nishizawa (S)

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. yusuke.sato.a7@tohoku.ac.jp.
ORCID: 0000-0001-6303-2999

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Synthetic DNA binders for fluorescent sensing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Uracile › Thymine › Synthetic DNA binders for fluorescent sensing...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Synthetic DNA binders for fluorescent sensing...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Endonucleases › Synthetic DNA binders for fluorescent sensing...