Engineering Glucose Dehydrogenase to Favor Totally Synthetic Biomimetic Cofactors Containing Carboxyl Group.
biomimetic cofactors
glucose dehydrogenase
semi-rational design
virtual screening
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
01 08 2023
01 08 2023
Historique:
revised:
30
04
2023
received:
29
01
2023
medline:
2
8
2023
pubmed:
3
5
2023
entrez:
3
5
2023
Statut:
ppublish
Résumé
The utilization of unnatural nicotinamide cofactors for reactions catalyzed by oxidoreductases has gained increasing interest. Totally synthetic nicotinamide cofactor biomimetics (NCBs) are cost-effective and convenient to synthesize. Thus, it has become increasingly important to develop enzymes that accept NCBs. Here, we have engineered SsGDH to favor a newly synthesized unnatural cofactor 3-carbamoyl-1-(4-carboxybenzyl) pyridin-1-ium (BANA
Identifiants
pubmed: 37132452
doi: 10.1002/cbic.202300066
doi:
Substances chimiques
Glucose 1-Dehydrogenase
EC 1.1.1.47
Oxidoreductases
EC 1.-
Niacinamide
25X51I8RD4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300066Informations de copyright
© 2023 Wiley-VCH GmbH.
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