Gestational ethanol exposure impairs motor skills in female mice through dysregulated striatal dopamine and acetylcholine function.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
14
12
2022
accepted:
21
04
2023
revised:
29
03
2023
medline:
23
10
2023
pubmed:
16
5
2023
entrez:
15
5
2023
Statut:
ppublish
Résumé
Fetal alcohol exposure has deleterious consequences on the motor skills of patients affected by Fetal Alcohol Spectrum Disorder (FASD) and in pre-clinical models of gestational ethanol exposure (GEE). Deficits in striatal cholinergic interneurons (CINs) and dopamine function impair action learning and execution, yet the effects of GEE on acetylcholine (ACh) and striatal dopamine release remain unexplored. Here, we report that alcohol exposure during the first ten postnatal days (GEE
Identifiants
pubmed: 37188849
doi: 10.1038/s41386-023-01594-4
pii: 10.1038/s41386-023-01594-4
pmc: PMC10579353
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Acetylcholine
N9YNS0M02X
Ethanol
3K9958V90M
Nicotinic Agonists
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1808-1820Subventions
Organisme : Intramural NIH HHS
ID : ZIA AA000416
Pays : United States
Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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