The molecular basis of heterochromatin assembly and epigenetic inheritance.
epigenetic
heterochromatin
histone methylation
inheritance
read-write
silencing
Journal
Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
received:
26
10
2022
revised:
10
04
2023
accepted:
20
04
2023
pmc-release:
01
06
2024
medline:
5
6
2023
pubmed:
20
5
2023
entrez:
19
5
2023
Statut:
ppublish
Résumé
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and silencing of repetitive DNA elements. Histone modifications are essential for the establishment of heterochromatin domains, which is initiated by the recruitment of histone-modifying enzymes to nucleation sites. This leads to the deposition of histone H3 lysine-9 methylation (H3K9me), which provides the foundation for building high-concentration territories of heterochromatin proteins and the spread of heterochromatin across extended domains. Moreover, heterochromatin can be epigenetically inherited during cell division in a self-templating manner. This involves a "read-write" mechanism where pre-existing modified histones, such as tri-methylated H3K9 (H3K9me3), support chromatin association of the histone methyltransferase to promote further deposition of H3K9me. Recent studies suggest that a critical density of H3K9me3 and its associated factors is necessary for the propagation of heterochromatin domains across multiple generations. In this review, I discuss the key experiments that have highlighted the importance of modified histones for epigenetic inheritance.
Identifiants
pubmed: 37207657
pii: S1097-2765(23)00291-5
doi: 10.1016/j.molcel.2023.04.020
pmc: PMC10309086
mid: NIHMS1896593
pii:
doi:
Substances chimiques
Histones
0
Heterochromatin
0
Schizosaccharomyces pombe Proteins
0
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
Types de publication
Journal Article
Review
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1767-1785Subventions
Organisme : Intramural NIH HHS
ID : Z01 BC010523
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 CA999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC010523
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC011208
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests The author is a member of the Molecular Cell advisory board.
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