Game of Omes: ribosome profiling expands the MHC-I immunopeptidome.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
12
03
2023
revised:
25
04
2023
accepted:
26
04
2023
pmc-release:
01
08
2024
medline:
7
8
2023
pubmed:
30
5
2023
entrez:
29
5
2023
Statut:
ppublish
Résumé
Peptide ligands presented by cell-surface MHC class-I molecules enable T cells to eradicate intracellular pathogens and cancers. The presented peptide repertoire, the class-I immunopeptidome, is generated from each cell's translatome in a highly biased manner to avoid overrepresenting highly abundant translation products. The immunopeptidome can only be defined by mass spectrometry (MS). Here, we review recent advances in immunopeptidomics, focusing on using ribosome profiling as the optimal MS database to optimize the false- and failed-discovery rates and relate these findings to the contribution of defective ribosomal products and cellular quality control mechanisms to MHC class-I antigen processing and presentation.
Identifiants
pubmed: 37247567
pii: S0952-7915(23)00061-4
doi: 10.1016/j.coi.2023.102342
pmc: PMC10524008
mid: NIHMS1899185
pii:
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Peptides
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102342Subventions
Organisme : Intramural NIH HHS
ID : Z99 AI999999
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors of the submitted paper, namely, Jonathan W. Yewdell and Jaroslav Holly, declare no conflict of interest.
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