Amide Skeletal Elongation via Amino Acid Insertion.
amide activation
amide synthesis
amino acid insertion
rearrangement
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
15 Aug 2023
15 Aug 2023
Historique:
received:
30
05
2023
medline:
17
8
2023
pubmed:
1
6
2023
entrez:
1
6
2023
Statut:
ppublish
Résumé
Amide derivatization is useful to access valuable organic compounds considering the ready availability of molecules containing amide functionality. Current methods to derivatize amide mainly focus on the synthesis of carbonyl-containing compounds and amines. Incorporating both parts of the initial amide into the new derivatives is rare. Herein, we describe a simple and practical amide derivatization through amino acid insertion to prepare more complex amides. This insertion is applicable to a wide range of amino acids and more importantly, the chiral information is completely conserved during the insertion. Comparison of this insertion strategy with conventional amide synthesis demonstrates the synthetic advantages of this new protocol.
Identifiants
pubmed: 37259820
doi: 10.1002/chem.202301729
doi:
Substances chimiques
Amides
0
Amino Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202301729Informations de copyright
© 2023 Wiley-VCH Verlag GmbH.
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