A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution.
anemia
evolution
heme
iron
nitric oxide
physiology
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
01
05
2023
received:
28
03
2023
accepted:
04
05
2023
pmc-release:
01
08
2024
medline:
26
7
2023
pubmed:
5
6
2023
entrez:
5
6
2023
Statut:
ppublish
Résumé
A natural heme deficiency that exists in cells outside of the circulation broadly compromises the heme contents and functions of heme proteins in cells and tissues. Recently, we found that the signaling molecule, nitric oxide (NO), can trigger or repress the deployment of intracellular heme in a concentration-dependent hormetic manner. This uncovers a new role for NO and sets the stage for it to shape numerous biological processes by controlling heme deployment and consequent heme protein functions in biology.
Identifiants
pubmed: 37276366
doi: 10.1002/bies.202300055
pmc: PMC10478511
mid: NIHMS1902744
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Heme
42VZT0U6YR
Hemeproteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300055Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM130624
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL081064
Pays : United States
Organisme : NIH HHS
ID : HL150049
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL150049
Pays : United States
Organisme : NIH HHS
ID : HL081064
Pays : United States
Organisme : NIH HHS
ID : GM130624
Pays : United States
Informations de copyright
© 2023 The Authors. BioEssays published by Wiley Periodicals LLC.
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