Triflylpyridinium as Coupling Reagent for Rapid Amide and Ester Synthesis.

Amides Esters Peptides Carboxylic Acids

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
23 Jun 2023
Historique:
medline: 26 6 2023
pubmed: 9 6 2023
entrez: 8 6 2023
Statut: ppublish

Résumé

An effective method has been developed to facilitate the synthesis of amides and esters at ambient temperature within 5 min, in which a stable and easily accessible triflylpyridinium reagent is used. Remarkably, this method not only has a wide range of substrate compatibility but also could realize the scalable synthesis of peptide and ester via a continuous flow process. Moreover, excellent chirality retentions are presented during activation of carboxylic acid.

Identifiants

DOI: 10.1021/acs.orglett.3c01598 PMID: 37290965
pubmed: 37290965
doi: 10.1021/acs.orglett.3c01598
doi:

Substances chimiques

Amides 0
Esters 0
Peptides 0
Carboxylic Acids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4571-4575

Auteurs

Du Chen (D)

State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Liangxuan Xu (L)

State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Bowen Ren (B)

State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Zian Wang (Z)

State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Chao Liu (C)

State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0002-2521-924X

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amides › Triflylpyridinium as Coupling Reagent for...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Esters › Triflylpyridinium as Coupling Reagent for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Triflylpyridinium as Coupling Reagent for...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Triflylpyridinium as Coupling Reagent for...