Electrochemical nucleic acid sensors: Competent pathways for mobile molecular diagnostics.

Nucleic Acids Biosensing Techniques Pathology, Molecular Electrochemical Techniques Nucleic Acid Hybridization
Electrochemical biosensor Microfluidic chip Mobile molecular diagnosis Nucleic acid

Journal

Biosensors & bioelectronics
ISSN: 1873-4235
Titre abrégé: Biosens Bioelectron
Pays: England
ID NLM: 9001289

Informations de publication

Date de publication:
01 Oct 2023
Historique:
received: 28 01 2023
revised: 10 05 2023
accepted: 15 05 2023
medline: 14 8 2023
pubmed: 10 6 2023
entrez: 9 6 2023
Statut: ppublish

Résumé

Electrochemical nucleic acid biosensor has demonstrated great promise in clinical diagnostic tests, mainly because of its flexibility, high efficiency, low cost, and easy integration for analytical applications. Numerous nucleic acid hybridization-based strategies have been developed for the design and construction of novel electrochemical biosensors for diagnosing genetic-related diseases. This review describes the advances, challenges, and prospects of electrochemical nucleic acid biosensors for mobile molecular diagnosis. Specifically, the basic principles, sensing elements, applications in diagnosis of cancer and infectious diseases, integration with microfluidic technology and commercialization are mainly included in this review, aiming to provide new insights and directions for the future development of electrochemical nucleic acid biosensors.

Identifiants

DOI: 10.1016/j.bios.2023.115407 PMID: 37295136
pubmed: 37295136
pii: S0956-5663(23)00349-4
doi: 10.1016/j.bios.2023.115407
pii:
doi:

Substances chimiques

Nucleic Acids 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

115407

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Huijie Bai (H)

Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.

Yong Wang (Y)

Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.

Xiaosong Li (X)

Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China. Electronic address: lixiaosong@cqmu.edu.cn.

Jinhong Guo (J)

Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China; School of Sensing Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › Electrochemical nucleic acid sensors:...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Electrochemical nucleic acid sensors:...
questionsmedicales.fr › Professions de santé › Médecine › Anatomopathologie › Anatomopathologie moléculaire › Electrochemical nucleic acid sensors:...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Electrochemical nucleic acid sensors:...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Hybridation d'acides nucléiques › Electrochemical nucleic acid sensors:...