α-Tocopherol-13'-Carboxychromanol Induces Cell Cycle Arrest and Cell Death by Inhibiting the SREBP1-SCD1 Axis and Causing Imbalance in Lipid Desaturation.
SCD1
SREBP1
adaptive stress response
apoptosis
lipid desaturation
macrophages
α-T-13′-COOH
α-tocopherol-derived long-chain metabolite
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 May 2023
25 May 2023
Historique:
received:
18
04
2023
revised:
19
05
2023
accepted:
23
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
α-Tocopherol-13'-carboxychromanol (α-T-13'-COOH) is an endogenously formed bioactive α-tocopherol metabolite that limits inflammation and has been proposed to exert lipid metabolism-regulatory, pro-apoptotic, and anti-tumoral properties at micromolar concentrations. The mechanisms underlying these cell stress-associated responses are, however, poorly understood. Here, we show that the induction of G
Identifiants
pubmed: 37298183
pii: ijms24119229
doi: 10.3390/ijms24119229
pmc: PMC10253185
pii:
doi:
Substances chimiques
alpha-Tocopherol
H4N855PNZ1
Tocopherols
R0ZB2556P8
Sterol Regulatory Element Binding Protein 1
0
Fatty Acids
0
Vitamin E
1406-18-4
Stearoyl-CoA Desaturase
EC 1.14.19.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : RTG1715
Organisme : Free State of Thuringia and the European Social Fund
ID : 2019 FGR 0095
Organisme : IMPULSE
ID : DRM/2019-01
Organisme : Deutsche Forschungsgemeinschaft
ID : KO4589/7-1
Organisme : FWF Austrian Science Fund
ID : P 36299
Organisme : FWF Austrian Science Fund
ID : I 4968
Organisme : Phospholipid Research Center Heidelberg
ID : AKO-2019-070/2-1
Organisme : Phospholipid Research Center Heidelberg
ID : AKO-2O22-100/2-2
Organisme : Free State of Thuringia and the European Social Fund
ID : 2016 FGR 0045
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