Photoredox Catalytic Installation of an Alkyl/Aryl Side Chain and Deuterium into (

Deuterium / chemistry Amino Acids / chemistry Catalysis

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
30 Jun 2023
Historique:
medline: 3 7 2023
pubmed: 16 6 2023
entrez: 16 6 2023
Statut: ppublish

Résumé

A photoredox catalytic asymmetric method has been established for the installation of both aliphatic and aromatic side chains and the introduction of deuterium into the chiral methyleneoxazolidinone simultaneously. Efficient coupling of readily available boronic acids with the chiral auxiliary delivers structurally diverse α-deuterated α-amino acid derivatives with a high level of diastereoselectivity and deuteration.

Identifiants

DOI: 10.1021/acs.orglett.3c01760 PMID: 37326373
pubmed: 37326373
doi: 10.1021/acs.orglett.3c01760
doi:

Substances chimiques

Deuterium AR09D82C7G
Amino Acids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4745-4749

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM125920
Pays : United States

Auteurs

Yue Dong (Y)

Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, United States.

Xiang Meng (X)

Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, United States.

Giri Gnawali (G)

Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, United States.

Mengyang Chang (M)

Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.

Wei Wang (W)

Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, United States.
Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
BIO5 Institute, University of Arizona, Tucson, Arizona 85721, United States.
ORCID: 0000-0001-6043-0860

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Deutérium › Photoredox Catalytic Installation of an...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Photoredox Catalytic Installation of an...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Photoredox Catalytic Installation of an...