B-Cell-Activating Factor Contributes to Elevation of the Content of Regulatory B Cells in Neonatal Sepsis.
Infant, Newborn
Humans
B-Lymphocytes, Regulatory
/ metabolism
Proto-Oncogene Proteins c-akt
/ genetics
Neonatal Sepsis
/ metabolism
Phosphatidylinositol 3-Kinases
/ genetics
Lipopolysaccharides
/ pharmacology
TOR Serine-Threonine Kinases
/ genetics
Interleukin-4
/ metabolism
Antigens, CD19
/ metabolism
B cell-activating factor (BAFF)
PI3K/AKT/mTOR signaling pathway
neonatal
regulatory B cell
sepsis
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
02
06
2022
medline:
28
6
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
ppublish
Résumé
We studied the role of B cell-activating factor (BAFF) in PI3K/AKT/mTOR signaling pathway in promoting proliferation and maintaining survival of regulatory B lymphocytes (Breg) in newborns with sepsis. The peripheral blood samples were collected from preterm neonates (n=40) diagnosed with sepsis on the day of diagnosis and on days 7, 14, and 21 after diagnosis, as well as from the matched preterm neonates without sepsis (n=40; control group). The peripheral blood mononuclear cells and B cells were isolated, cultured, and stimulated with LPS and immunostimulant CpG-oligodeoxynucleotide (CpG-ODN). Proliferation and differentiation of B-cells into CD19
Identifiants
pubmed: 37338768
doi: 10.1007/s10517-023-05814-1
pii: 10.1007/s10517-023-05814-1
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Lipopolysaccharides
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Interleukin-4
207137-56-2
Antigens, CD19
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-77Informations de copyright
© 2023. Springer Science+Business Media, LLC, part of Springer Nature.
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