Autoimmune alleles at the major histocompatibility locus modify melanoma susceptibility.

Humans Alleles Melanoma / genetics CD8-Positive T-Lymphocytes / metabolism Skin Neoplasms / genetics Histocompatibility Histocompatibility Antigens Class I / genetics
autoimmunity major histocompatibility complex melanoma polygenic risk scores

Journal

American journal of human genetics
ISSN: 1537-6605
Titre abrégé: Am J Hum Genet
Pays: United States
ID NLM: 0370475

Informations de publication

Date de publication:
06 07 2023
Historique:
received: 13 07 2022
revised: 20 05 2023
accepted: 22 05 2023
pmc-release: 06 01 2024
medline: 10 7 2023
pubmed: 21 6 2023
entrez: 20 6 2023
Statut: ppublish

Résumé

Autoimmunity and cancer represent two different aspects of immune dysfunction. Autoimmunity is characterized by breakdowns in immune self-tolerance, while impaired immune surveillance can allow for tumorigenesis. The class I major histocompatibility complex (MHC-I), which displays derivatives of the cellular peptidome for immune surveillance by CD8

Identifiants

DOI: 10.1016/j.ajhg.2023.05.013 PMID: 37339630 PMC: PMC10357503
pubmed: 37339630
pii: S0002-9297(23)00170-2
doi: 10.1016/j.ajhg.2023.05.013
pmc: PMC10357503
pii:
doi:

Substances chimiques

Histocompatibility Antigens Class I 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1138-1161

Subventions

Organisme : NCI NIH HHS
ID : R01 CA220009
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH122688
Pays : United States
Organisme : NLM NIH HHS
ID : T15 LM011271
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA248138
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103504
Pays : United States
Organisme : CSRD VA
ID : I01 CX001727
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests G.P.M. receives research support from Thermo Fisher, CareDx, and PIRCHE. M.Z. is a board member of Invectys Inc.

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Auteurs

James V Talwar (JV)

Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA.

David Laub (D)

Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA.

Meghana S Pagadala (MS)

Biomedical Science Program, University of California San Diego, La Jolla, CA 92093, USA.

Andrea Castro (A)

Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA.

McKenna Lewis (M)

Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.

Georg E Luebeck (GE)

Public Health Sciences Division, Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Bryan R Gorman (BR)

Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA 02130, USA; Booz Allen Hamilton, Inc., McLean, VA 22102, USA.

Cuiping Pan (C)

Palo Alto Epidemiology Research and Information Center for Genomics, VA Palo Alto, CA, USA.

Frederick N Dong (FN)

Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA 02130, USA; Booz Allen Hamilton, Inc., McLean, VA 22102, USA.

Kyriacos Markianos (K)

Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA 02130, USA; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02115, USA.

Craig C Teerlink (CC)

Department of Veterans Affairs Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Healthcare System, Salt Lake City, UT, USA; Department of Internal Medicine, Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Julie Lynch (J)

Department of Veterans Affairs Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Healthcare System, Salt Lake City, UT, USA; Department of Internal Medicine, Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Richard Hauger (R)

VA San Diego Healthcare System, La Jolla, CA, USA; Center for Behavioral Genetics of Aging, University of California San Diego, La Jolla, CA, USA; Center of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA, USA.

Saiju Pyarajan (S)

Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA 02130, USA; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.

Philip S Tsao (PS)

Palo Alto Epidemiology Research and Information Center for Genomics, VA Palo Alto, CA, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Gerald P Morris (GP)

Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA.

Rany M Salem (RM)

Division of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA 92093, USA.

Wesley K Thompson (WK)

Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74136, USA.

Kit Curtius (K)

Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Maurizio Zanetti (M)

Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; The Laboratory of Immunology, University of California San Diego, La Jolla, CA 92093, USA; Department of Medicine, Division of Hematology and Oncology, University of California San Diego, La Jolla, CA 92093, USA.

Hannah Carter (H)

Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: hkcarter@health.ucsd.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Autoimmune alleles at the major...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Autoimmune alleles at the major...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Autoimmune alleles at the major...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Autoimmune alleles at the major...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Autoimmune alleles at the major...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Histocompatibilité › Autoimmune alleles at the major...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes d'histocompatibilité de classe I › Autoimmune alleles at the major...