Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice.
Journal
Nature plants
ISSN: 2055-0278
Titre abrégé: Nat Plants
Pays: England
ID NLM: 101651677
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
25
07
2022
accepted:
24
05
2023
medline:
21
7
2023
pubmed:
23
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
NARROW LEAF 1 (NAL1) is a breeding-valuable pleiotropic gene that affects multiple agronomic traits in rice, although the molecular mechanism is largely unclear. Here, we report that NAL1 is a serine protease and displays a novel hexameric structure consisting of two ATP-mediated doughnut-shaped trimeric complexes. Moreover, we identified TOPLESS-related corepressor OsTPR2 involved in multiple growth and development processes as the substrate of NAL1. We found that NAL1 degraded OsTPR2, thus modulating the expression of downstream genes related to hormone signalling pathways, eventually achieving its pleiotropic physiological function. An elite allele, NAL1
Identifiants
pubmed: 37349549
doi: 10.1038/s41477-023-01449-2
pii: 10.1038/s41477-023-01449-2
doi:
Substances chimiques
Serine Endopeptidases
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1130-1142Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31930080
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31821005
Organisme : Postdoctoral Research Foundation of China (China Postdoctoral Research Foundation)
ID : 2019M652669
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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