Coarse-grained simulations of von Willebrand factor adsorption to collagen with consequent platelet recruitment.
platelets
thrombosis
von Willebrand factor
Journal
International journal for numerical methods in biomedical engineering
ISSN: 2040-7947
Titre abrégé: Int J Numer Method Biomed Eng
Pays: England
ID NLM: 101530293
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
18
05
2023
received:
21
10
2022
accepted:
11
06
2023
medline:
30
11
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
A multimeric glycoprotein of blood plasma-Von Willebrand factor (VWF)-mediates platelet adhesion to the fibrillar collagen of the subendothelial matrix if the blood vessel walls are damaged. The adsorption of VWF to collagen is thus essential for the initial stages of platelet hemostasis and thrombosis, as it plays a role of a molecular bridge between the injury and platelet adhesion receptors. Biomechanical complexity and sensitivity to the hydrodynamics are inherent in this system, therefore, modern computational methods supplement experimental studies of biophysical and molecular mechanisms that underlie platelet adhesion and aggregation in the blood flow. In the present paper, we propose a simulation framework for the VWF-mediated platelet adhesion to a plane wall with immobilized binding sites for VWF under the action of shear flow. VWF multimers and platelets are represented in the model by particles connected by elastic bonds and immersed in a viscous continuum fluid. This work complements the scientific field by taking into account the shape of a flattened platelet, but keeping a compromise between the detail of the description and the computational complexity of the model.
Substances chimiques
von Willebrand Factor
0
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3747Subventions
Organisme : Russian Science Foundation
ID : 22-21-00221
Informations de copyright
© 2023 John Wiley & Sons Ltd.
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