Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome.
Journal
Cancer research communications
ISSN: 2767-9764
Titre abrégé: Cancer Res Commun
Pays: United States
ID NLM: 9918281580506676
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
07
10
2022
revised:
19
01
2023
accepted:
29
03
2023
medline:
30
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer-predisposition disorder. Approximately 70% of individuals who fit the clinical definition of LFS harbor a pathogenic germline variant in the Our study clarifies the genomic basis for the phenotypic variability in LFS and highlights the immense benefits of expanding genetic and epigenetic testing of patients with LFS beyond
Identifiants
pubmed: 37377903
doi: 10.1158/2767-9764.CRC-22-0402
pii: CRC-22-0402
pmc: PMC10150777
doi:
Substances chimiques
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
738-754Informations de copyright
© 2023 The Authors; Published by the American Association for Cancer Research.
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