Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii.

Molecular Structure Hypericum / chemistry alpha-Glucosidases Magnetic Resonance Spectroscopy Glycoside Hydrolase Inhibitors / pharmacology
Chemical constituents Hypericum sampsonii Molecular docking Structure elucidation α-Glucosidase

Journal

Chinese journal of natural medicines
ISSN: 1875-5364
Titre abrégé: Chin J Nat Med
Pays: China
ID NLM: 101504416

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 12 10 2022
medline: 7 7 2023
pubmed: 6 7 2023
entrez: 5 7 2023
Statut: ppublish

Résumé

This study employed the α-glucosidase inhibitory activity model as an anti-diabetic assay and implemented a bioactivity-guided isolation strategy to identify novel natural compounds with potential therapeutic properties. Hypericum sampsoniiwas investigated, leading to the isolation of two highly modified seco-polycyclic polyprenylated acylphloroglucinols (PPAPs) (1 and 2), eight phenolic derivatives (3-10), and four terpene derivatives (11-14). The structures of compounds 1 and 2, featuring an unprecedented octahydro-2H-chromen-2-one ring system, were fully characterized using extensive spectroscopic data and quantum chemistry calculations. Six compounds (1, 5-7, 9, and 14) exhibited potential inhibitory effects against α-glucosidase, with IC

Identifiants

DOI: 10.1016/S1875-5364(23)60472-8 PMID: 37407175
pubmed: 37407175
pii: S1875-5364(23)60472-8
doi: 10.1016/S1875-5364(23)60472-8
pii:
doi:

Substances chimiques

alpha-Glucosidases EC 3.2.1.20
Glycoside Hydrolase Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

443-453

Informations de copyright

Copyright © 2023 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Auteurs

Linlan Tao (L)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China.

Shuangyu Xu (S)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China.

Zizhen Zhang (Z)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China.

Yanan Li (Y)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China.

Jue Yang (J)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China.

Wei Gu (W)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China.

Ping Yi (P)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China. Electronic address: yiping2100@aliyun.com.

Xiaojiang Hao (X)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: haoxj@mail.kib.ac.cn.

Chunmao Yuan (C)

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; Natural Products Research Center of Guizhou Province, Guiyang 550014, China. Electronic address: yuanchunmao01@126.com.

Articles similaires

Drug repurposing against fucosyltransferase-2 via docking, STD-NMR, and molecular dynamic simulation studies.

Muhammad Atif, Humaira Zafar, Atia-Tul- Wahab et al.
1.00
Fucosyltransferases Drug Repositioning Molecular Docking Simulation Molecular Dynamics Simulation Humans

Nitrile glove composition and performance-Substandard properties and inaccurate packaging information.

Ashley Herkins, Sriloy Dey, Dan Conroy et al.
1.00
Nitriles Tensile Strength Materials Testing Gloves, Protective Product Packaging

The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale.

Hannah K Wayment-Steele, Renee Otten, Warintra Pitsawong et al.
1.00
Rhodobacter sphaeroides Bacterial Proteins Circadian Rhythm Protein Folding Protein Conformation

Pharmacophore-based 3D-QSAR modeling, virtual screening, docking, molecular dynamics and biological evaluation studies for identification of potential inhibitors of alpha-glucosidase.

Unnati Kushavah, Pinaki Prasad Mahapatra, Shakil Ahmed et al.
1.00
Glycoside Hydrolase Inhibitors Quantitative Structure-Activity Relationship Molecular Docking Simulation alpha-Glucosidases Molecular Dynamics Simulation

Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Bioassay-guided isolation of α-Glucosidase...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Clusiaceae › Hypericum › Bioassay-guided isolation of α-Glucosidase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Bioassay-guided isolation of α-Glucosidase...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Bioassay-guided isolation of α-Glucosidase...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Bioassay-guided isolation of α-Glucosidase...