Translational regulation by uORFs and start codon selection stringency.

Codon, Initiator / genetics Protein Biosynthesis Codon / metabolism Ribosomes / genetics RNA, Messenger / genetics Open Reading Frames / genetics
ATF4 GCN4 eIF2 phosphorylation ribosome queuing stringency uORF

Journal

Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660

Informations de publication

Date de publication:
01 06 2023
Historique:
medline: 20 7 2023
pubmed: 12 7 2023
entrez: 11 7 2023
Statut: ppublish

Résumé

In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing 5' of the mORF start site. Whereas translation of uORFs generally represses translation of the mORFs, a subset of uORFs serves as a nexus for regulating translation of the mORF. In this review, we summarize the mechanisms by which uORFs can repress or stimulate mRNA translation, highlight uORF-mediated translational repression involving ribosome queuing, and critically evaluate recently described alternatives to the delayed reinitiation model for uORF-mediated regulation of the

Identifiants

DOI: 10.1101/gad.350752.123 PMID: 37433636 PMC: PMC10393191
pubmed: 37433636
pii: gad.350752.123
doi: 10.1101/gad.350752.123
pmc: PMC10393191
doi:

Substances chimiques

Codon, Initiator 0
Codon 0
RNA, Messenger 0

Types de publication

Journal Article Review Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

474-489

Informations de copyright

Published by Cold Spring Harbor Laboratory Press.

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Auteurs

Thomas E Dever (TE)

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA thomas.dever@nih.gov ivaylo.ivanov@nih.gov ahinnebusch@nih.gov.

Ivaylo P Ivanov (IP)

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA thomas.dever@nih.gov ivaylo.ivanov@nih.gov ahinnebusch@nih.gov.

Alan G Hinnebusch (AG)

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA thomas.dever@nih.gov ivaylo.ivanov@nih.gov ahinnebusch@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Codon › Codon d'initiation › Translational regulation by uORFs and start...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › Translational regulation by uORFs and start...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Codon › Translational regulation by uORFs and start...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Ribosomes › Translational regulation by uORFs and start...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Translational regulation by uORFs and start...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Cadres ouverts de lecture › Translational regulation by uORFs and start...