The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression.
Dbp5/DDX19
NGD
NSD
mRNA export
mRNA quality control
translation termination
Journal
Biological chemistry
ISSN: 1437-4315
Titre abrégé: Biol Chem
Pays: Germany
ID NLM: 9700112
Informations de publication
Date de publication:
26 07 2023
26 07 2023
Historique:
received:
10
02
2023
accepted:
03
07
2023
medline:
8
9
2023
pubmed:
12
7
2023
entrez:
12
7
2023
Statut:
epublish
Résumé
Cell viability largely depends on the surveillance of mRNA export and translation. Upon pre-mRNA processing and nuclear quality control, mature mRNAs are exported into the cytoplasm via Mex67-Mtr2 attachment. At the cytoplasmic site of the nuclear pore complex, the export receptor is displaced by the action of the DEAD-box RNA helicase Dbp5. Subsequent quality control of the open reading frame requires translation. Our studies suggest an involvement of Dbp5 in cytoplasmic no-go-and non-stop decay. Most importantly, we have also identified a key function for Dbp5 in translation termination, which identifies this helicase as a master regulator of mRNA expression.
Identifiants
pubmed: 37436777
pii: hsz-2023-0130
doi: 10.1515/hsz-2023-0130
doi:
Substances chimiques
Nucleocytoplasmic Transport Proteins
0
DEAD-box RNA Helicases
EC 3.6.4.13
Saccharomyces cerevisiae Proteins
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
845-850Informations de copyright
© 2023 the author(s), published by De Gruyter, Berlin/Boston.
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